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Statistical Mechanics of Allosteric Enzymes [PDF]
Journal Physical Chemistry B 120 (2016) 6021-6037, 2017 The concept of allostery in which macromolecules switch between two different conformations is a central theme in biological processes ranging from gene regulation to cell signaling to enzymology. Allosteric enzymes pervade metabolic processes, yet a simple and unified treatment of the effects of allostery in enzymes has been lacking.
arxiv +1 more source
Machine learning modeling of family wide enzyme-substrate specificity screens [PDF]
, 2021 Biocatalysis is a promising approach to sustainably synthesize pharmaceuticals, complex natural products, and commodity chemicals at scale. However, the adoption of biocatalysis is limited by our ability to select enzymes that will catalyze their natural chemical transformation on non-natural substrates.
arxiv +1 more source
European Heart Journal, 2020 Aims The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin–angiotensin–aldosterone system (
I. Sama +17 more
semanticscholar +1 more source
EXPERT CONSENSUS DOCUMENT ON ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN CARDIOVASCULAR DISEASE
Рациональная фармакотерапия в кардиологии, 2015 Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease.
Jose Lopez-Sendon +10 more
doaj +3 more sources
A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth
Asian Pacific Journal of Tropical Biomedicine, 2019 Objective: To isolate, identify, and evaluate a new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth herbs. Methods: A dried sample of Peperomia pellucida herb was successively macerated with n-hexane and ethyl acetate.
Islamudin Ahmad +7 more
doaj +1 more source
PLoS ONE, 2022 The outbreak of the coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 triggered a global pandemic where control is needed through therapeutic and preventive interventions. This study aims to identify natural compounds
Tomokazu Ohishi +6 more
doaj +2 more sources
Pharmacological effects of raas blockade in ischemic nephropathy [PDF]
, 2016 Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio +8 more
core +1 more source
Absolute diffusion measurements of active enzyme solutions by NMR [PDF]
, 2018 The diffusion of enzymes is of fundamental importance for many biochemical processes. Enhanced or directed enzyme diffusion can alter the accessibility of substrates and the organization of enzymes within cells. Several studies based on fluorescence correlation spectroscopy (FCS) report enhanced diffusion of enzymes upon interaction with their ...
arxiv +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Comments to the paper G. Savarese et al. A Meta-Analysis Reporting Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients Without Heart ...
S. Yu. Martsevich
doaj +3 more sources
Numerical calculation of protein-ligand binding rates through solution of the Smoluchowski equation using smooth particle hydrodynamics [PDF]
BMC Biophys. 2015; 8: 7, 2015 Background. The calculation of diffusion-controlled ligand binding rates is important for understanding enzyme mechanisms as well as designing enzyme inhibitors. We demonstrate the accuracy and effectiveness of a Lagrangian particle-based method, smoothed particle hydrodynamics (SPH), to study diffusion in biomolecular systems by numerically solving ...
arxiv +1 more source