Results 61 to 70 of about 184,127 (310)

A Computational Journey Toward an Optimal Design for Metamaterial Epicardial Passive Sleeves

Advanced Healthcare Materials, EarlyView.
Passive epicardial sleeves are evaluated in 3D in‐silico heart models to reveal how sleeve geometry, stiffness, anisotropy, and metamaterial architecture influence cardiac mechanics after myocardial infarction. A continuum‐to‐auxetic design exploration shows that region‐specific mechanical engagement can reduce infarct bulging and modulate torsional ...
Vahid Naeini, Emilio A. Mendiola, Ahmad Rafsanjani, Fergal B. Coulter, Qian Xiang, Jianyi Zhang, Peter Vanderslice, Vahid Serpooshan, Reza Avazmohammadi   +8 more
wiley   +1 more source

ACE-inhibitor induced angioedema masked by nephrotic syndrome

Southwest Respiratory and Critical Care Chronicles, 2016
Angiotensin-converting enzyme (ACE) inhibitors are the leading cause of drug-induced angioedema in the United States because these drugs are widely prescribed for several common medical disorders. Angiotensin-converting enzyme inhibitors cause angioedema
Kenneth Iwuji, Hezekiah Sobamowo, James Tarbox, Rose Egbe   +3 more
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Comparison of different strategies to measure medication adherence via claims data in patients with chronic heart failure [PDF]

, 2019
Medication adherence correlates with morbidity and mortality in patients with chronic heart failure (CHF), but is difficult to assess. We conducted a retrospective methodological cohort study in 3,808 CHF patients, calculating adherence as proportion of ...
Griese‐Mammen, Nina, Ihle, Peter, Krueger, Katrin, Laufs, Ulrich, Parrau, Natalie, Schubert, Ingrid, Schulz, Martin   +6 more
core   +1 more source

Microscopically Adaptable Bioink Guide Cell Compartmentalization toward Morphogenesis of a Functional Vasculature‐Like System

Advanced Healthcare Materials, EarlyView.
Contractile vasculatures are fabricated through a one‐step bioprinting strategy. The adaptable microenvironment provided by ECM‐mimicking bioink triggers cell sorting and compartmentalization of endothelial cells and vascular smooth muscle cells toward a histological configuration by focal adhesion kinase‐mediated upregulation of cell adhesion and ...
Jun Chen, Yuqiong Wu, Jiarong Huang, Junjin Jie, Chan Huang, Di Zhang, Yuxin Huang, Rui Mao, Ming Zhao, Lin‐Ping Wu   +9 more
wiley   +1 more source

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Evidence From Randomized Controlled Trials (RCTs) of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II–Receptor Blockers — Questions Remain Unsolved

Journal of Pharmacological Sciences, 2010
Recent randomized controlled trials showed that blockade of the renin–angiotensin system (RAS) by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II–receptor blockers (ARBs) reduced cardiovascular and renal events.
Shinichiro Ueda
doaj   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac Reverse Remodeling: Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The angiotensin‐receptor neprilysin inhibitor (ARNI) sacubitril/valsartan was shown to be superior to the angiotensin‐converting enzyme inhibitor enalapril in terms of reducing cardiovascular mortality in the PARADIGM‐HF (Prospective ...
Yiwen Wang, Ran Zhou, Chi Lu, Qing Chen, Tongda Xu, Dongye Li   +5 more
doaj   +1 more source

Health services research in the public healthcare system in Hong Kong: An analysis of over 1 million antihypertensive prescriptions between 2004-2007 as an example of the potential and pitfalls of using routinely collected electronic patient data [PDF]

, 2008
<b>Objectives</b> Increasing use is being made of routinely collected electronic patient data in health services research. The aim of the present study was to evaluate the potential usefulness of a comprehensive database used routinely in the
A McCormack, AL Nightingale, Augustine Lam, AW Hoes, DM Fleming, EE Degli, EPIC, F Trevisani, G Edgren, G Mazzaglia, GC Smith, GL Booth, H Ueshima, Hong Fung, I Nazareth, I Nazareth, InterASIA Collaborative group, J Hollowell, JA Cassell, JB Soriano, JE Hux, JI Williams, Jin-ling Tang, JK Jones, Johnny Y Jiang, JR Hardy, K Tu, KM Madsen, M Ezzati, Martin CS Wong, PM Kearney, R Gupta, R Jones, R Lawrenson, R Lawrenson, RB Singh, RB Singh, RG Gibbs, RJ Cruz-Correia, S Capewell, SS Soedamah-Muthu, Stewart W Mercer, T Karopka, T Walley, TA Burke, TM McKeever, TR Mikuls, TR Mikuls   +47 more
core   +4 more sources

Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays

Advanced Materials, EarlyView.
A bioelectronic sensor integrating 2D cell membranes with organic microelectrode arrays enables detection of SARS‐CoV‐2 fusion pathways. Natively‐expressed viral receptors promote monitoring of viral entry and screening of antibody‐based inhibitors.
Zixuan Lu, Jeremy Treiber, Konstantinos Kallitsis, Ekaterina Selivanovitch, Alexandra Wheeler, Maria Lopez‐Cavestany, Zhongmou Chao, Sarah L Barron, Ju An Park, Darius Hoven, Anna Scheeder, Aimee Withers, Becky M. Hess, Clemens F. Kaminski, Alberto Salleo, Anna‐Maria Pappa, Susan Daniel, Róisín M Owens   +17 more
wiley   +1 more source

Neutrophil hypersegmentation in children receiving angiotensin converting enzyme inhibitors

The Turkish Journal of Pediatrics, 2008
Captopril and enalapril are the most commonly used angiotensin converting enzyme inhibitors in several cardiac diseases in children. On the other hand, the intrinsic renin-angiotensin system in the bone marrow might affect the growth of ...
Vedat Okutan, A Emin Kürekçi, S Umit Sarici, A Avni Atay, Yilmaz Yozgat, Fatih Azik, M Koray Lenk, Okan Ozcan   +7 more
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