Blockade of the renin-angiotensin system [PDF]
, 2002 The renin-angiotensin-aldosterone system plays a key role in the regulation of fluid and electrolyte balance. Angiotensin-converting enzyme inhibitors inhibit angiotensin-converting enzyme and have been shown to be effective in many cardiovascular ...
Cheung, BMY
core
The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]
, 2012 Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Alison Seed +62 more
core +2 more sources
Enzyme promiscuity prediction using hierarchy-informed multi-label classification [PDF]
arXiv, 2020 As experimental efforts are costly and time consuming, computational characterization of enzyme capabilities is an attractive alternative. We present and evaluate several machine-learning models to predict which of 983 distinct enzymes, as defined via the Enzyme Commission, EC, numbers, are likely to interact with a given query molecule.
arxiv
British Journal of Clinical Pharmacology, 2018 Angiotensin‐converting enzyme inhibitors (ACEIs) are widely prescribed for several cardiovascular indications. This study investigated patterns of ACEI use for various indications.
S. H. Mahmoudpour +4 more
semanticscholar +1 more source
The effectiveness of zofenopril in patients with cardiovascular disease [PDF]
Системные гипертензии, 2014 Hyperactivity of the renin-angiotensin-aldosterone system plays an important role in the pathogenesis of any cardiovascular disease. Angiotensin - converting enzyme inhibitors are the main drugs among many medicines influencing the activity of the renin ...
V G Kukes, G S Anikin
doaj
Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts. [PDF]
, 2020 Background and objectives: 2018 ESC/ESH Hypertension guideline recommends 2-drug combination as initial anti-hypertensive therapy. However, real-world evidence for effectiveness of recommended regimens remains limited.
Cho, Jaehyeong +10 more
core +2 more sources
Angiotensin-Converting Enzyme Inhibitors and the Risk of Congenital Malformations.
Obstetrics and Gynecology, 2017 OBJECTIVE To examine the association between first-trimester angiotensin-converting enzyme (ACE) inhibitor exposure and the risk of overall major congenital, cardiac, and central nervous system malformations.
B. Bateman +9 more
semanticscholar +1 more source
New potent inhibitors of angiotensin converting enzyme [PDF]
, 1984 Using an earlier model of the favoured orientation of binding functions of angiotensin converting enzyme (ACE) inhibitors, it has been possible to postulate a new, 7,6-bicyclic system, based on hexahydropyridazine, which might be expected to have high ...
Attwood, Michael R. +8 more
core +1 more source
Virtual screening of Microalgal compounds as potential inhibitors of Type 2 Human Transmembrane serine protease (TMPRSS2) [PDF]
arXiv, 2021 More than 198 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported that result in no fewer than 4.2 million deaths globally. The rapid spread of the disease coupled with the lack of specific registered drugs for its treatment pose a great challenge that necessitate the development of therapeutic agents from a ...
arxiv
В мире научных открытий, 2016 The article discusses the effectiveness of 3-month therapy with angiotensin converting enzyme inhibitors fosinopril receptor and antagonists of the angiotensin II valsartan to achieve target BP(
Zarina Vyacheslavovna Bitarovа +3 more
doaj +1 more source