Results 81 to 90 of about 268,538 (298)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background The angiotensin‐receptor neprilysin inhibitor (ARNI) sacubitril/valsartan was shown to be superior to the angiotensin‐converting enzyme inhibitor enalapril in terms of reducing cardiovascular mortality in the PARADIGM‐HF (Prospective ...
Yiwen Wang +5 more
doaj +1 more source
Angiotensin Blockade in Patients with Diabetic Nephropathy [PDF]
, 2007 When used to delay the progression of early nephropathy in patients with type 2 diabetes mellitus, angiotensin receptor blockers (ARBs) are not superior to angiotensin-converting enzyme (ACE) inhibitors.
Jimenez, Julio, Safranek, Sarah
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Effect of amaranth proteins on the RAS system: In vitro, in vivo and ex vivo assays [PDF]
, 2020 The aim of this work was to analyse the hypotensive effect of amaranthprotein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo.
Aphalo, Paula +4 more
core +2 more sources
Docking Studies on HIV Integrase Inhibitors Based On Potential Ligand Binding Sites [PDF]
International Journal on Bioinformatics & Biosciences, vol. 2, pp.
21-29, 2012, 2012 HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Integrase is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell.
arxiv +1 more source
Haseki Tıp Bülteni, 2023 Aim:Angiotensin-converting enzyme 2 (ACE2) acts not only as an enzyme but also as a thought to be central receptor by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters host cells.
Dilay Satilmis +2 more
doaj +1 more source
British medical journal, 2013 Objectives To assess whether a double therapy combination consisting of diuretics, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers with addition of non-steroidal anti-inflammatory drugs (NSAIDs) and the triple therapy ...
F. Lapi +4 more
semanticscholar +1 more source
Predicting inhibitors for SARS-CoV-2 RNA-dependent RNA polymerase using machine learning and virtual screening [PDF]
arXiv, 2020 Global coronavirus disease pandemic (COVID-19) caused by newly identified SARS- CoV-2 coronavirus continues to claim the lives of thousands of people worldwide. The unavailability of specific medications to treat COVID-19 has led to drug repositioning efforts using various approaches, including computational analyses.
arxiv
Rigidity analysis of HIV-1 protease [PDF]
J. Phys.: Conf. Ser. 286, 012006, (2011), 2011 We present a rigidity analysis on a large number of X-ray crystal structures of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software FIRST. We find that although the rigidity profile remains similar across a comprehensive set of high resolution structures, the profile changes significantly in the presence of an inhibitor.
arxiv +1 more source
Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. [PDF]
, 2018 Background Our objective was to determine patterns of antihypertensive agent use by stage of chronic kidney disease (CKD) and to evaluate the association between different classes of antihypertensive agents with nonrenal outcomes, especially in advanced ...
Johansen, Kirsten L +4 more
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Raționalitatea utilizării inhibitorilor sistemului renină-angiotensină la pacienții cu patologie cardiovasculară și oftalmică [PDF]
, 2020 Background. It has been established that components of the renin-angiotensin system are present in ocular structures and may play an important role in regulating ocular physiological processes and the pathogenesis of diabetic retinopathy, glaucoma, age-
Bacinschi, Andrei
core