Results 91 to 100 of about 466,155 (352)

Coronavirus Disease 2019 (COVID‐19): Do Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Have a Biphasic Effect?

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
report from 138 hospitalized COVID- 19 patients, 31% had hypertension, 10% had diabetes mellitus, and 14.5% had cardiovascular disease, being the 3 most common comorbidities. 11 In the latter study, 36 of the 138 patients needed intensive care unit stays,
R. Sommerstein, M. Kochen, F. Messerli, C. Gräni   +3 more
semanticscholar   +1 more source

Angiotensin Blockade in Patients with Diabetic Nephropathy [PDF]

, 2007
When used to delay the progression of early nephropathy in patients with type 2 diabetes mellitus, angiotensin receptor blockers (ARBs) are not superior to angiotensin-converting enzyme (ACE) inhibitors.
Jimenez, Julio, Safranek, Sarah
core  

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Allen, James M., Baker, Andrew H., Chamberlain, Jeffrey S., Craig, Margaret Anne, Dominiczak, Anna F., Gilday, Kirsten, Graham, Delyth, Gregorevic, Paul, Masson, Rachel, McBride, Martin, Napoli, Claudio, Nicklin, Stuart A., Smith, Godfrey   +12 more
core   +1 more source

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

Advanced Science, EarlyView.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu   +7 more
wiley   +1 more source

Comparison of Pharmacy Refill Data With Chemical Adherence Testing in Assessing Medication Nonadherence in a Safety Net Hospital Setting

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Pharmacy fill data are a practical tool for assessing medication nonadherence. However, previous studies have not compared the accuracy of pharmacy fill data to measurement of plasma drug levels, or chemical adherence testing (CAT).
David Osula, Bryan Wu, Kevin Schesing, Sandeep R. Das, Elizabeth Moss, Kristin Alvarez, Christopher Clark, Ethan A. Halm, Nancy J Brown, Wanpen Vongpatanasin   +9 more
doaj   +1 more source

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Critical Care, 2017
BackgroundRenin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS).
Akram Khan, Cody Benthin, B. Zeno, T. Albertson, J. Boyd, J. Christie, R. Hall, G. Poirier, J. Ronco, M. Tidswell, K. Hardes, W. Powley, T. Wright, S. Siederer, D. Fairman, D. Lipson, Andrew I. Bayliffe, A. Lazaar   +17 more
semanticscholar   +1 more source

The effect of chronic peripheral nesfatin-1 application on blood pressure in normal and chronic restraint stressed rats: Related with circulating level of blood pressure regulators [PDF]

, 2015
Nesfatin is a peptide secreted by peripheral tissues, central and peripheral nervous system. It is involved in the regulation of homeostasis. Although the effects of nesfatin-1 on nutrition have been studied widely in the literature, the mechanisms of ...
Ayada, C., Güçlü, Z., Turgut, Günfer, Turgut, Sebahat   +3 more
core   +1 more source

Angiotensin-Converting Enzyme Inhibitors and Angioedema [PDF]

Allergy, Asthma and Immunology Research, 2010
To investigate the incidence and clinical characteristics of angioedema associated with the use of angiotensin-converting enzyme inhibitors (ACEIs) in an outpatient allergy department.A retrospective review of medical records of new patients seen in an allergy clinic.
Luis González-Aveledo, Mario Sánchez-Borges   +1 more
openaire   +3 more sources

Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease

Advanced Science, EarlyView.
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu, Ting Huang, Ying Hong, Yuqi Yang, Wensheng Chen, Qingtao Zeng, Qiaohui Chen, Yongqi Yang, Xiaohong Ying, Wan Zeng, Ziyu Wu, Tianjiao Zhao, Xuesi Wan, Jianlin Chen, Kelong Ai, Qiong Huang   +15 more
wiley   +1 more source

Angiotensin I converting enzyme. [PDF]

Circulation Research, 1975
Many of the properties of angiotensin I converting enzyme or kininase II (ACE) have been discussed in extenso in the literature. The mode of action of ACE inhibitors has been studied in experimental animals and used clinically in millions of patients. The relatively few side effects have also been amply scrutinized.
openaire   +3 more sources