Results 11 to 20 of about 349,498 (354)

Angiotensin-Converting Enzyme Inhibitors [PDF]

Circulation, 1998
Abstract—ACE inhibitors have achieved widespread usage in the treatment of cardiovascular and renal disease. ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and hypertrophic properties of angiotensin II (Ang II) and the vasodilatory and natriuretic properties of bradykinin and alter the metabolism of a number of other ...
N J, Brown, D E, Vaughan
openaire   +2 more sources

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

Critical Care, 2020
An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic.
W. Ni, Xiuwen Yang, Deqing Yang, J. Bao, Ran Li, Yongjiu Xiao, C. Hou, Haibin Wang, Jie Liu, Dong-hong Yang, Yu Xu, Zhaolong Cao, Zhancheng Gao   +12 more
semanticscholar   +1 more source

Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1

Frontiers in Immunology, 2021
Multiple lines of evidence have demonstrated that cigarette smoke or Chronic Obstructive Pulmonary Disease upregulates angiotensin-converting enzyme 2, the cellular receptor for the entry of the severe acute respiratory syndrome coronavirus 2, which ...
Jing Yang, Edith A. Perez, Changchun Hou, Pin Zhang, Michelle Van Scoyk, Robert A. Winn, Lijun Rong, Jing Liu   +7 more
doaj   +1 more source

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

Circulation Research, 2020
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory ...
Mahmoud Gheblawi, Kaiming Wang, A. Viveiros, Quynh Nguyen, J. Zhong, A. Turner, M. Raizada, M. Grant, G. Oudit   +8 more
semanticscholar   +1 more source

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Nature Medicine, 2005
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world. A new coronavirus (SARS-CoV) was identified as the SARS pathogen, which triggered severe pneumonia and acute ...
K. Kuba, Y. Imai, Shuan Rao, Hong Gao, F. Guo, Bin Guan, Yi Huan, Peng‐fei Yang, Yanli Zhang, Wei Deng, L. Bao, Binlin Zhang, Guang Liu, Z. Wang, M. Chappell, Yan-xin Liu, D. Zheng, A. Leibbrandt, T. Wada, Arthur S Slutsky, De-Pei Liu, C. Qin, Chengyu Jiang, J. Penninger   +23 more
semanticscholar   +1 more source

Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)

Journal of Pathology, 2020
Angiotensin‐converting enzyme 2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for the current devastating worldwide pandemic of coronavirus disease 2019
A. Bourgonje, A. Abdulle, W. Timens, J. Hillebrands, G. Navis, Sanne J Gordijn, M. Bolling, Gerard Dijkstra, A. Voors, A. Osterhaus, Peter H. J. van der Voort, D. J. Mulder, H. van Goor   +12 more
semanticscholar   +1 more source

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults.

Journal of the American Medical Association (JAMA), 2020
This study compares angiotensin-converting enzyme 2 (ACE2) gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.
S. Bunyavanich, Anh N. Do, A. Vicencio
semanticscholar   +1 more source

A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To isolate, identify, and evaluate a new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth herbs. Methods: A dried sample of Peperomia pellucida herb was successively macerated with n-hexane and ethyl acetate.
Islamudin Ahmad, Neneng Siti Silfi Ambarwati, Berna Elya, Hanita Omar, Kamarza Mulia, Arry Yanuar, Osamu Negishi, Abdul Mun´im   +7 more
doaj   +1 more source

Angiotensin-Converting Enzyme and Heart Failure

Frontiers in Bioscience-Landmark, 2023
Pharmacotherapy is the cornerstone treatment for patients with heart failure (HF) that uses drugs targeting the renin-angiotensin-aldosterone system (RAAS), including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs ...
Sara Álvarez-Zaballos, Manuel Martínez-Sellés   +1 more
doaj   +1 more source

Renin‐angiotensin aldosterone profile before and after angiotensin‐converting enzyme‐inhibitor administration in dogs with angiotensin‐converting enzyme gene polymorphism

Journal of Veterinary Internal Medicine, 2020
Background An angiotensin‐converting enzyme (ACE) gene polymorphism occurs in dogs; however, functional importance is not well studied. Hypothesis We hypothesized that dogs with the polymorphism would show alternative renin‐angiotensin aldosterone system
Darcy Adin, Clarke Atkins, Oliver Domenig, Teresa DeFrancesco, Bruce Keene, Sandra Tou, Joshua A. Stern, Kathryn M. Meurs   +7 more
doaj   +1 more source