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Angiotensin converting enzyme inhibitors
Pharmaceutisch Weekblad Scientific Edition, 1982Inhibition of angiotensin converting enzyme (ACE) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally active ACE inhibitor and the structure-activity relationship of captopril analogues are described.
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Angiotensin-Converting Enzyme Inhibition, Angiotensin, and Cognition
Journal of Cardiovascular Pharmacology, 1992In these studies, we have investigated possible cognition-enhancing effects of angiotensin-converting enzyme (ACE) inhibition, and putative neurochemical correlates for these actions. In a mouse habituation model, ACE inhibitors improved basal performance and antagonized scopolamine-induced deficits.
J M, Barnes +7 more
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The angiotensin converting enzyme (ACE)
The International Journal of Biochemistry & Cell Biology, 2003Angiotensin converting enzyme 1, found widely throughout the animal kingdom, is an integral membrane bound protein whose active sites are directed to the extracellular spaces. Two isoforms are expressed in mammals, a single domain germinal isoform required for male fertility, and a double domain somatic isoform which has a key role in the renin ...
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Angiotensin-converting enzyme inhibitors
2001Publisher Summary Angiotensin-converting enzyme (ACE) inhibitors were first studied clinically in the 1970s. ACE inhibitors were discovered by taking advantage of previous basic research on the physiology of sodium, potassium, and water homeostasis and blood pressure regulation, in a reciprocal way ACE have also advanced research in this field, and ...
J, Menard, A A, Patchett
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Renin and angiotensin converting enzyme in elasmobranchs
General and Comparative Endocrinology, 1992Renin-like activity (RLA) and angiotensin I converting enzyme-like activity (ACELA), the two key enzymes of the renin-angiotensin system (RAS), were sought in the elasmobranch Scyliorhinus canicula. Renal extracts were desalted in a G-25 and eluted in a G-100 Sephadex column (calibration 15,000-70,000).
B. Uva +5 more
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Angiotensin‐Converting Enzyme in Sarcoidosis
Acta Medica Scandinavica, 1979ABSTRACT Using a spectrophotometric assay with l‐hippuryl‐l‐histidyl‐l‐leucine as substrate, s‐angio‐tensin‐converting enzyme (SACE) was determined in 85 sarcoidosis patients, 116 healthy controls and 150 patients with various non‐sarcoid diseases. The controls showed no sex or age variation and had SACE levels of 24.4±6.2 U/ml (mean ± 1 S.D.), giving ...
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Angiotensin-Converting Enzyme Inhibitors
Medical Clinics of North America, 1987In summary, ACE inhibitors are effective in reducing blood pressure as initial therapy in some hypertensive patients and in combination with diuretics and other agents in virtually all hypertensives. ACE inhibitors are uniquely advantageous because of their favorable hemodynamic effects, the lack of adverse metabolic effects, and their ability to ...
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Angiotensin-Converting Enzyme Inhibitors
AACN Advanced Critical Care, 1992The angiotensin-converting enzyme (ACE) inhibitors available today include Captopril (Capoten), enalapril (Vasotec), enaloprilat (Vasotec IV), lisinopril (Prinivil, Zestril), benazepril (Lotensin), fosinopril (Monopril), and ramipril (Atace). These drugs are used in the treatment of hypertension and congestive heart failure.
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The Leech Angiotensin‐Converting Enzyme
Annals of the New York Academy of Sciences, 1998V, Laurent, G B, Stefano, M, Salzet
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