Results 61 to 70 of about 227,212 (304)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]

, 2005
BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema, Paul J Robinson, Morrell, Nicholas W, Peter G Phillips, Shakur B Haleema, Matthew A Higham, B Haleema Shakur, Robinson Paul J, Nicholas W Morrell, Ray J Beddoes, Robinson, Paul J, Beddoes, Ray J, Beddoes Ray J, Higham, Matthew A, Phillips Peter G, Phillips, Peter G, Higham Matthew A, Morrell Nicholas W   +17 more
core   +1 more source

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

Effect of Aerobic Training on Concentration of Plasma Angiotensin-Converting Enzyme (ACE) in Postmenopausal Women

مجله دانشکده پزشکی اصفهان, 2015
Background: Angiotensin converting enzyme (ACE) is secreted from vascular endothelium. This enzyme is one of the main determinants of blood pressure regulation.
Maryam Mirhaj, Elahe Talebi-Garakani, Rozita Fathi, Alireza Safarzadeh   +3 more
doaj  

Hidrolisis Protein Tanduk Muda Rusa Sambar (Rusa unicolor) serta Potensinya sebagai Penurun Resiko Hipertensi

Journal of Tropical Pharmacy and Chemistry, 2016
Penelitian  ini  bertujuan  untuk  mengetahui  tingkat  hidrolisis  tanduk muda rusa Sambar (Rusa unicolor) dengan  enzim  pencernaanm  yaitu  enzim  pepsin  dan tripsin,  serta  mengetahui  adanya  aktivitas  Angiotensin  I-Converting Enzyme Inhibitor ...
Arif Ismanto
doaj   +1 more source

Do ACE inhibitors improve the response to exercise training in functionally impaired older adults? A randomized controlled trial [PDF]

, 2014
<br>Background: Loss of muscle mass and strength with ageing is a major cause for falls, disability, and morbidity in older people. Previous studies have found that angiotensin-converting enzyme inhibitors (ACEi) may improve physical function in ...
Sumukadas, Deepa, Cvoro, Vera, McMurdo, Marion, Lloyd, Suzanne M., Band, Margaret, Miller, Suzanne, Witham, Miles, Struthers, Allan, McConnachie, Alex   +8 more
core   +1 more source

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, EarlyView.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source