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Discrimination of two angiotensin II receptor subtypes with a selective agonist analogue of angiotensin II, p-aminophenylalanine6 angiotensin II

Biochemical and Biophysical Research Communications, 1990
Angiotensin II receptor binding sites in rat liver and PC12 cells differ in their affinities for a nonpeptidic antagonist, DuP 753, and p-aminophenylalanine6 angiotensin II. In liver, which primarily contains the sulfhydryl reducing agent-inhibited type of angiotensin II receptor, which we refer to as the AII alpha subtype, DuP 753 displays an IC50 of ...
Kwan Hee Kim, Robert C. Speth
openaire   +3 more sources

Angiotensin II

Journal of Cardiovascular Pharmacology, 1991
The consequence of a sustained rise in blood pressure is an adaptive change in the structure of the heart and the vasculature. In humans, the left ventricle, aorta, and medium-sized arteries undergo hypertrophy whereas the changes in resistance vessels are unclear at present.
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Angiotensin II and the locus coeruleus

1991
The locus coeruleus (LC) is a putative site of action for angiotensin II in the brain. Immunocytochemical studies have identified angiotensin II-like immunoreactive material in nerve terminals innervating the LC, and the LC contains one of the highest densities of angiotensin II receptor binding sites in the rat brain.
Speth, R. C., Grove, K. L., Rowe, B. P.
openaire   +4 more sources

Angiotensin II-Generating Enzymes

Biochemistry (Moscow), 2000
The renin--angiotensin system (RAS) is a system of enzymes and hormones that regulate blood pressure and electrolyte and fluid homeostasis in mammals. Angiotensin II (Ang-II) is one of the most important and well-known components of RAS. It is formed from the protein precursor angiotensinogen by the sequential actions of proteolytic enzymes.
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Angiotensin II Receptors and Angiotensin II-Stimulated Signal Transduction

Heart Failure Reviews, 1998
Originally known to be a vasoconstrictor and thought to play a critical role in hypertension, angiotensin II has recently emerged to be important in inflammation, atherosclerosis, and congestive heart failure. The discovery of selective angiotensin II receptor antagonists has enabled specific functions to be assigned to at least three angiotensin ...
openaire   +2 more sources

Angiotensin-II

Reactions weekly, 2020

semanticscholar   +1 more source

Angiotensin II Blockade

New England Journal of Medicine, 1977
Keenan Re, Conklin Vm, Horne Ml
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Withholding versus Continuing Angiotensin-converting Enzyme Inhibitors or Angiotensin II Receptor Blockers before Noncardiac Surgery: An Analysis of the Vascular events In noncardiac Surgery patIents cOhort evaluatioN Prospective Cohort

Anesthesiology, 2017
P. Roshanov   +22 more
semanticscholar   +1 more source

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

American Journal of Physiology - Cell Physiology, 2007
P. Mehta, K. Griendling
semanticscholar   +1 more source

Intrarenal role of angiotensin II and [des-Asp1]angiotensin II

American Journal of Physiology-Renal Physiology, 1979
Thomas G. Coleman   +4 more
openaire   +3 more sources

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