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Biochemical and Biophysical Research Communications, 1990
Angiotensin II receptor binding sites in rat liver and PC12 cells differ in their affinities for a nonpeptidic antagonist, DuP 753, and p-aminophenylalanine6 angiotensin II. In liver, which primarily contains the sulfhydryl reducing agent-inhibited type of angiotensin II receptor, which we refer to as the AII alpha subtype, DuP 753 displays an IC50 of ...
Kwan Hee Kim, Robert C. Speth
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Angiotensin II receptor binding sites in rat liver and PC12 cells differ in their affinities for a nonpeptidic antagonist, DuP 753, and p-aminophenylalanine6 angiotensin II. In liver, which primarily contains the sulfhydryl reducing agent-inhibited type of angiotensin II receptor, which we refer to as the AII alpha subtype, DuP 753 displays an IC50 of ...
Kwan Hee Kim, Robert C. Speth
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Journal of Cardiovascular Pharmacology, 1991
The consequence of a sustained rise in blood pressure is an adaptive change in the structure of the heart and the vasculature. In humans, the left ventricle, aorta, and medium-sized arteries undergo hypertrophy whereas the changes in resistance vessels are unclear at present.
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The consequence of a sustained rise in blood pressure is an adaptive change in the structure of the heart and the vasculature. In humans, the left ventricle, aorta, and medium-sized arteries undergo hypertrophy whereas the changes in resistance vessels are unclear at present.
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Angiotensin II and the locus coeruleus
1991The locus coeruleus (LC) is a putative site of action for angiotensin II in the brain. Immunocytochemical studies have identified angiotensin II-like immunoreactive material in nerve terminals innervating the LC, and the LC contains one of the highest densities of angiotensin II receptor binding sites in the rat brain.
Speth, R. C., Grove, K. L., Rowe, B. P.
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Angiotensin II-Generating Enzymes
Biochemistry (Moscow), 2000The renin--angiotensin system (RAS) is a system of enzymes and hormones that regulate blood pressure and electrolyte and fluid homeostasis in mammals. Angiotensin II (Ang-II) is one of the most important and well-known components of RAS. It is formed from the protein precursor angiotensinogen by the sequential actions of proteolytic enzymes.
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Angiotensin II Receptors and Angiotensin II-Stimulated Signal Transduction
Heart Failure Reviews, 1998Originally known to be a vasoconstrictor and thought to play a critical role in hypertension, angiotensin II has recently emerged to be important in inflammation, atherosclerosis, and congestive heart failure. The discovery of selective angiotensin II receptor antagonists has enabled specific functions to be assigned to at least three angiotensin ...
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Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
American Journal of Physiology - Cell Physiology, 2007P. Mehta, K. Griendling
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Intrarenal role of angiotensin II and [des-Asp1]angiotensin II
American Journal of Physiology-Renal Physiology, 1979Thomas G. Coleman+4 more
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