Results 351 to 360 of about 2,811,792 (409)

Angiotensin II Receptor Heterogeneity

American Journal of Hypertension, 1991
The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of our earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes.
William F. Herblin, Andrew T. Chiu, Dale E. McCall, Robert J. Ardecky, David J. Carini, John V. Duncia, Lori J. Pease, Pancras C. Wong, Ruth R. Wexler, Alexander L Johnson, Pieter B.M.W.M. Timmermans   +10 more
openaire   +2 more sources

Human angiotensin receptor subtypes

Current Opinion in Nephrology and Hypertension, 1994
The rapid expansion of our knowledge of angiotensin receptors has been led by the development of subtype-specific angiotensin II receptor antagonists and by the cloning and sequencing of the AT1 receptor in angiotensin II. Although some actions of angiotensin II have been attributed to AT2 subtype receptors, the importance of these binding sites ...
Ronald D. Smith, &NA; Pieter, &NA; Timmermans   +2 more
openaire   +2 more sources

Tachyphylaxis and angiotensin receptors

General Pharmacology: The Vascular System, 1976
Angiotensin tachyphylaxis was studied in the isolated guinea pig ileum under isometric conditions. 2. In tachyphylactic organs, the initial phasic response to angiotensin was abolished, while the tonic component of the response became faster in its onset and in its reversal (relaxation). 3.
Paiva, T. B., Aboulafia, J., Nouailhetas, VLA, Paiva, ACM   +3 more
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Angiotensin II Receptor Subtypes

American Journal of Hypertension, 1992
The octapeptide, angiotensin II (Ang II), the biologically active component of the renin-angiotensin system, elicits its multiple actions through the stimulation of specific surface receptors on various target organs. Although the existence of Ang II receptor subtypes has been suspected for some time, definitive evidence for Ang II receptor ...
P B, Timmermans, A T, Chiu, W F, Herblin, P C, Wong, R D, Smith   +4 more
openaire   +2 more sources

Angiotensin II receptor antagonists

The Lancet, 2000
Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral activity, achieved by shortening the original peptide structures, transformed the probes into therapeutic agents, the angiotensin-converting enzyme (ACE) inhibitors.
M, Burnier, H R, Brunner
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Angiotensin and angiotensin receptors in cartilaginous fishes

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2001
In mammals, a principal bioactive component of the renin-angiotensin system (RAS), angiotensin II (ANG II), is known to be vasopressor, dipsogenic, a stimulant of adrenocortical secretion and to control glomerular and renal tubular function. Historically, a RAS analogous to that found in mammals was thought to have first evolved in the bony fishes ...
ANDERSON W. G, CERRA, Maria Carmela, WELLS A., TIERNEY M. L., TOTA B., TAKEI Y., HAZON . N.   +6 more
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Angiotensin receptor blockers and angiotensin receptor–neprilysin inhibitors

2022
Abstract This chapter addresses angiotensin receptor blockers (ARBs) and angiotensin receptor–neprilysin inhibitors (ARNIs). ARBs or angiotensin II receptor antagonists were introduced as a potentially superior alternative to an angiotensin converting enzyme (ACE) inhibitor and, later, as a possible addition to an ACE inhibitor.
openaire   +1 more source

Angiotensin II Receptor Assays

Current Protocols in Pharmacology, 1998
AbstractThis unit describes the use of an isolated rabbit thoracic aorta preparation for determining the nature, potency, and selectivity of antagonists to the agonism of angiotensin II at AT1 receptors by measuring their effects on the tension of the tissue.
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Angiotensin AT4 Receptor

2004
Although angiotensin IV (Ang IV) was thought initially to be an inactive product of angiotensin II (Ang II) degradation, the hexapeptide was subsequently shown to markedly enhance learning and memory in normal rodents and reverse memory deficits observed in animal models of amnesia. These central nervous system effects of Ang IV are mediated by binding
S. Y. Chai, F. A. O. Mendelsohn, J. Lee, T. Mustafa, S. G. McDowall, A. L. Albiston   +5 more
openaire   +1 more source

ANGIOTENSIN RECEPTORS

Biochemical Pharmacology, 1978
M A, Devynck, P, Meyer
openaire   +2 more sources