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Mild hypothermia alleviates post-resuscitation cerebral injury in rats via modulating the balance of the renin–angiotensin system [PDF]
Resuscitation PlusCardiac arrest and cardiopulmonary resuscitation represent a major cause of mortality. Cerebral ischemia–reperfusion injury following Cardiac arrest and cardiopulmonary resuscitation leads to severe neurological deficits and significantly worsens patient
Yongjing He +8 more
doaj +2 more sources
Physiopathology of the Brain Renin-Angiotensin System [PDF]
LifeThe renin-angiotensin system (RAS) has evolved from being considered solely a peripheral endocrine system for cardiovascular control to being recognized as a complex molecular network with important functions in the central nervous system (CNS) and ...
Cristina Cueto-Ureña +3 more
doaj +2 more sources
APOL1 Modulates Renin–Angiotensin System [PDF]
BiomoleculesPatients carrying APOL1 risk alleles (G1 and G2) have a higher risk of developing Focal Segmental Glomerulosclerosis (FSGS); we hypothesized that escalated levels of miR193a contribute to kidney injury by activating renin–angiotensin system (RAS) in the ...
Vinod Kumar +11 more
doaj +2 more sources
Renin-Angiotensin System: A Review of Historical Perspectives
Galician Medical Journal, 2023 The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova +2 more
doaj +1 more source
Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease.
New England Journal of Medicine, 2022 BACKGROUND Renin-angiotensin system (RAS) inhibitors - including angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) - slow the progression of mild or moderate chronic kidney disease.
S. Bhandari +7 more
semanticscholar +1 more source
Renin Angiotensin System and Covid-19 Infection [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose The new coronavirus, called SARS-CoV-2, is responsible for the recent global pandemic COVID-19. The status of the global pandemic COVID-19 is currently underway, and the virus has caused about 1.11 million deaths.
Francesco Ferrara, Antonio Vitiello
doaj +1 more source
A New Perspective on the Renin-Angiotensin System
Diagnostics, 2022 Cardiovascular disease (CVD) is the leading cause of death in the world. Hypertension is a serious medical problem not only in adults but also in children and adolescents.
A. Martyniak, P. Tomasik
semanticscholar +1 more source
The Lancet Respiratory Medicine, 2021 Background Biological considerations suggest that renin–angiotensin system inhibitors might influence the severity of COVID-19. We aimed to evaluate whether continuing versus discontinuing renin–angiotensin system inhibitors (angiotensin-converting ...
Jordana B. Cohen +32 more
semanticscholar +1 more source
Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
Circulation Research, 2020 ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory ...
Mahmoud Gheblawi +8 more
semanticscholar +1 more source
The renin-angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts.
Kidney international. Supplement, 2022 A large body of evidence implicates the renin-angiotensin system in the pathogenesis of cardiovascular disease. However, not everyone understands that the magnitude of the risk reduction achieved in clinical trials with angiotensin-converting enzyme ...
C. Ferrario +6 more
semanticscholar +1 more source