Factors associated with angiotensin II stimulating vs. inhibiting antihypertensive drug use in older adults [PDF]
BMC GeriatricsBackground Limited understanding exists regarding factors associated with use of angiotensin II–inhibiting drugs (AIDs) vs. angiotensin II–stimulating drugs (ASDs), antihypertensive treatments increasingly studied for potential neuroprotective effects ...
Nistha Shrestha +6 more
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Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]
Kidney Research and Clinical Practice, 2023 Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha +3 more
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Angiotensin converting enzyme 2 (ACE2) - the major receptor for SARS-CoV-2 virus [PDF]
Farmacja Polska, 2021 The renin-angiotensin-aldosterone system (RAS) plays a significant role in the regulation of the water and electrolyte balance. Renin from the kidneys converts angiotensinogen to angiotensin I. Angiotensin converting enzyme (ACE) catalyzes the conversion
Sonia Frankowska +3 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Prolonged activation of angiotensin II is the main mediator that contributes to the development of heart diseases, so converting angiotensin II into angiotensin 1‐7 has emerged as a new strategy to attenuate detrimental effects of angiotensin ...
Binh Y. Nguyen +15 more
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Molecules, 2021 The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of designing and synthesizing non-peptide mimetics for oral administration.
John Matsoukas +6 more
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Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors. [PDF]
PLoS ONE, 2014 INTRODUCTION: Recently, we could show that angiotensin II, the reactive peptide of the blood pressure-regulating renin-angiotensin-aldosterone-system, causes the formation of reactive oxygen species and DNA damage in kidneys and hearts of hypertensive ...
Susanne Brand +4 more
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Angiotensin II facilitates fibrogenic effect of TGF-β1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II. [PDF]
PLoS ONE, 2013 Angiotensin II has progressively been considered to play an important role in the development of liver fibrosis, although the mechanism isn't fully understood.
Yu-Sheng Li +6 more
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Frontiers in Pharmacology, 2015 Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7 ...
Daniel eClayton +6 more
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Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor
Chinese Journal of Lung Cancer, 2016 Angiotensin AngII, a linear small peptide,which is composed of eight amino acids, is the main effectors of renin-angiotensin systen (Renin-angiotensin system, RAS).
Lulu SUN, Jian SHI
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Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling
Frontiers in Pharmacology, 2022 Vascular remodeling due to hypertension is one of the major health challenges facing countries around the world. Neohesperidin, a flavonoid glycoside found in citrus fruits, is an antioxidant.
Jingsi Zhang +7 more
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