Results 31 to 40 of about 365,351 (311)

Pathological Role of Angiotensin II in Severe COVID-19

TH Open, 2020
The activated renin–angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin–angiotensin system and is degraded by the ...
Wolfgang Miesbach
doaj   +1 more source

Mass-spectrometric identification of a novel angiotensin peptide in human plasma [PDF]

, 2007
Objective— Angiotensin peptides play a central role in cardiovascular physiology and pathology. Among these peptides, angiotensin II (Ang II) has been investigated most intensively.
Bader, Michael, Beyermann, Michael, Furkert, Jens, Gobom, Johan, Jankowski, Joachim, Jankowski, Vera, Karadogan, Sevil, Krause, Eberhard, Oksche, Alexander, Schlüter, Hartmut, Schuchardt, Mirjam, Tepel, Martin, Todiras, Mihail, Tran, Thi Nguyet Anh, Tölle, Markus, van der Giet, Markus, Vanholder, Raymond, Wiedon, Annette, Zidek, Walter   +18 more
core   +1 more source

Role of Angiotensin Receptor Type I and Type II in the Development of Common Cardiac Problems

Journal of the Practice of Cardiovascular Sciences
The renin–angiotensin system is crucial for maintaining blood pressure and fluid balance. Central to this system are the angiotensin receptors, type I (AT1R) and type II (AT2R), which mediate the effects of angiotensin II (Ang-II).
Tannistha Hota, Mainak Sengupta, Arunachal Chatterjee   +2 more
doaj   +1 more source

Angiotensin AT1 Receptor-associated protein Arap1 in the Kidney Vasculature is Suppressed by Angiotensin II [PDF]

, 2012
Arap1 is a protein that interacts with angiotensin II type 1 (AT1) receptors and facilitates increased AT1 receptor surface expression in vitro. In the present study, we assessed the tissue localization and regulation of Arap1 in vivo.
Castrop, Hayo, Doblinger, Elisabeth, Hansen, Pernille Bl, Hoecherl, Klaus, Jensen, Boye L, Kattler, Veronika, Mederle, Katharina, Walter, Steen   +7 more
core   +1 more source

Angiotensin Ii Receptor Blockers [PDF]

Baylor University Medical Center Proceedings, 2003
The ARBs have very similar clinical profiles. They do, however, have different pharmacokinetic profiles, which may lead to some differences in efficacy. The newer agents irbesartan, candesartan, telmisartan, and olmesartan have longer half-lives and durations of action than the older agents losartan and valsartan (5).
Amy, Barreras, Cheryle, Gurk-Turner
openaire   +2 more sources

Angiotensinergic innervation of rat and human mesenteric resistant blood vessels [PDF]

, 2007
In contrast to the current believe that angiotensin II (Ang II) only interacts with the sympathetic nervous system (SNS) as a circulating hormone, we document here the existence of an endogenous renin-angiotensin system (RAS) in the sympathetic coeliac ...
Eva Heiniger, Hans Imboden, Jaspal Patil, Oliver Muhlemann, Thomas Schaffner   +4 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy

Frontiers in Endocrinology
IntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity.
Paweł Pietruski, Katarzyna Kosińska-Kaczyńska, Agnieszka Osińska, Magdalena Zgliczyńska, Kinga Żebrowska, Katarzyna Popko, Anna Stelmaszczyk-Emmel   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Macrophages come to mind as keys to cognitive decline [PDF]

, 2016
Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al.
D.G. Harrison, Davies, Faraco, Launer, Liu, Tomasz J. Guzik   +5 more
core   +1 more source