Results 51 to 60 of about 6,209,552 (299)

Angiotensin Receptor Blocker (ARB): Is it Effective to Prevent Cerebral Malaria? [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases
Cerebral malaria is a severe complication of plasmodium falciparum infection with 15-25% mortality rates. Sequestration of infected red blood cells disrupts the blood brain barried leading to irreversible brain damage, impacting quality of life.
I Gusti Ayu Hiranandini Prawista, Davin Beta Tadeo, I Gusti Ngurah Ariestha Satya Diksha, Darren Junior, Richard Christian Suteja, Cokorda Agung Wahyu Purnamasidhi, Saktivi Harkitasari   +6 more
doaj   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Electronic sculpting of ligand-GPCR subtype selectivity:the case of angiotensin II [PDF]

, 2014
GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential.
Pappas, Charalampos G., Francesca Magnani, Jones, Emma S., Gerothanassis, Ioannis P., Emma S. Jones, Andreas G. Tzakos, Widdop, Robert E., Crook, Tim, Ishiguro, Susumu, Charalampos G. Pappas, Vassiliki Magafa, Tzakos, Andreas G., Naomi Ohta (735090), Jana Selent, Paul Cordopatis, Susumu Ishiguro, Ioannis P. Gerothanassis, Ohta, Naomi, Andreas G. Tzakos (1327620), Tim Crook, Naomi Ohta, Francesca Magnani (1327608), Ioannis P. Gerothanassis (1327626), Masaaki Tamura, Paul Cordopatis (1327614), Cordopatis, Paul, Sanja Bosnyak, Jana Selent (147923), Emma S. Jones (1327623), Robert E. Widdop (585063), Selent, Jana, Bosnyak, Sanja, Magnani, Francesca, Robert E. Widdop, Charalampos G. Pappas (1327617), Susumu Ishiguro (735091), Vassiliki Magafa (1327629), Sanja Bosnyak (1327611), Tamura, Masaaki, Masaaki Tamura (735096), Magafa, Vassiliki, Tim Crook (1069)   +41 more
core   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Angiotensin II antagonists

Revista Cubana de Cardiología y Cirugía Cardiovascular, 2014
The angiotensin II antagonists, a new group of drugs, block in a selective way AT receptors, causing vasodilatation, increase of renin and of angiotensin II, reduction of peripheral resistance, of the aldosterone levels, and of blood pressure without ...
David García Barreto, Alberto Hernández Cañero   +1 more
doaj  

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Chymase as an Important Target to Prevent Organ Damage

Journal of Pharmacological Sciences, 2010
Chymase plays a crucial role in angiotensin II formation in various tissues. Angiotensin II induces gene expression of transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors, and chymase can convert precursors of TGF-β and MMP-
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Endothelial Vasodilator Angiotensin Receptors are Changing in Mice with Ageing

Research in Molecular Medicine, 2014
Background: The vascular function of Angiotensin II-type-2 receptors in adults is controversial. We sought their location and function in mouse aortic rings at young and old mice.
Majid Malekzadeh Shafaroudi, Craig J Dlay   +1 more
doaj  

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source