Results 41 to 50 of about 235,819 (313)

Role of Angiotensin Receptor Type I and Type II in the Development of Common Cardiac Problems

Journal of the Practice of Cardiovascular Sciences
The renin–angiotensin system is crucial for maintaining blood pressure and fluid balance. Central to this system are the angiotensin receptors, type I (AT1R) and type II (AT2R), which mediate the effects of angiotensin II (Ang-II).
Tannistha Hota, Mainak Sengupta, Arunachal Chatterjee   +2 more
doaj   +1 more source

Angiotensin Ii Does Not Influence Expression of Sarcoplasmic Reticulum Ca2 + Atpase in Atrial Myocytes

, 2011
Introduction. The sarcoplasmic reticulum Ca2+ ATPase (SERCA) is essential for the regulation of the intracellular calcium level in cardiomyocytes. Previous studies have found that angiotensin 11 (Ang II) decreased SERCA2 gene expression in ventricular ...
吳卓鍇;曾春典;黃尹岑;謝佳珊;蔡維珊;林俊立;江福田;蔡佳醍, WU, CHO-KAI;TSENG, CHUEN-DEN;HUANG, YIN-TSEN;HSIEH, CHIA-SHAN;TSAI, WEI-SHAN;LIN, JIUNN-LEE;CHIANG, FU-TIEN;TSAI, CHIA-TI   +1 more
core   +1 more source

Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy.

, 2010
The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Staff, A.C., Luft, F.C., Mueller, D.N., Lydia Hering, Brosnihan, KB, Anne C. Staff, Berthold Huppertz, Katrin Wenzel, Wenzel, K., Brosnihan, K.B., Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Wenzel, K, Huppertz, B, Florian Herse, Staff, AC, Ralf Dechend, Nele Geusens, Cartwright, J.E., K. Bridget Brosnihan, Huppertz, B., Geusens, N., Hering, L, Dominik N. Muller, Dechend, R., Hering, L., Verlohren, S, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Molecular targeting therapy with angiotensin II receptor blocker for prostatic cancer

Oncology Reviews, 2011
Angiotensin II (Ang-II) plays a key role as a vasoconstrictor in controlling blood pressure and electrolyte/fluid homeostasis. Recently it has also been shown that this peptide is a cytokine, acting as a growth factor in cardiovascular and stromal cells.
Hiroji Uemura, Hitoshi Ishiguro, Yoshinobu Kubota   +2 more
doaj   +2 more sources

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]

, 2005
BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema, Paul J Robinson, Morrell, Nicholas W, Peter G Phillips, Shakur B Haleema, Matthew A Higham, B Haleema Shakur, Robinson Paul J, Nicholas W Morrell, Ray J Beddoes, Robinson, Paul J, Beddoes, Ray J, Beddoes Ray J, Higham, Matthew A, Phillips Peter G, Phillips, Peter G, Higham Matthew A, Morrell Nicholas W   +17 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease

Clinical and Experimental Hypertension, 2018
Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj   +1 more source