Results 1 to 10 of about 39,387 (167)

Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

Frontiers in Endocrinology, 2023
The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases.
Stepan Gambaryan, Sanika Mohagaonkar, Sanika Mohagaonkar, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +4 more
doaj   +1 more source

Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice

Frontiers in Cardiovascular Medicine, 2023
Background and objectiveWhole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex.
Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Yuriko Katsumata, Motoko Yanagita, Motoko Yanagita, Hisashi Sawada, Hisashi Sawada, Hisashi Sawada, Alan Daugherty, Alan Daugherty, Alan Daugherty, Hong S. Lu, Hong S. Lu, Hong S. Lu   +19 more
doaj   +1 more source

C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension

Frontiers in Bioscience-Landmark, 2023
Background: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood.
Chongjian Wang, Zhiyu Wang, Jing Xu, Hongkun Ma, Kexin Jin, Tingting Xu, Xiaoxia Pan, Xiaobei Feng, Wen Zhang   +8 more
doaj   +1 more source

Assessing treatment adherence is crucial to determine adequacy of mineralocorticoid therapy

Endocrine Connections, 2023
Background: There is no consensus strategy for mineralocorticoid (MC) therapy titration in patients with primary adrenal insufficiency (PAI). W e aim to measure serum fludrocortisone (sFC) and urine fludrocortisone (uFC) levels and to determine their ...
Riccardo Pofi, Ilaria Bonaventura, Joanne Duffy, Zoe Maunsell, Brian Shine, Andrea M Isidori, Jeremy W Tomlinson   +6 more
doaj   +1 more source

A randomized, double‐blind clinical trial to evaluate the blood pressure lowing effect of low‐sodium salt substitution on middle‐aged and elderly hypertensive patients with different plasma renin concentrations

The Journal of Clinical Hypertension, 2022
This study aimed to evaluate the blood pressure (BP) lowing effect of low‐sodium (LS) salt substitution and how the effect influenced by plasma renin concentration (PRC) on middle‐aged and elderly hypertensive patients.
Li Che, Wei Song, Ying Zhang, Yan Lu, Yunpeng Cheng, Yinong Jiang   +5 more
doaj   +1 more source

On the Specificity of Renin [PDF]

Science, 1940
Fil: Braun Menéndez, Eduardo. Instituto de Fisiología. Facultad de Medicina.
Fasciolo, Juan C., Leloir, Luis Federico, Muñoz, Juan M., Braun Menéndez, Eduardo   +3 more
openaire   +3 more sources

DIAGNOSIS OF ALDOSTEROMA. CLINICAL CASE

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
A clinical case of hyperaldosteronism identifed during hospitalization in the endocrinology department of the Healthcare Institution «Grodno University Clinic» is presented.
Nikonova L. V., Tishkovskiy S. V., Martinkevich O. N., Shidlovskaya О. А.   +3 more
doaj   +1 more source

Lack of Effects of Renin-Angiotensin-Aldosterone System Activity and Beta-Adrenoceptor Pathway Polymorphisms on the Response to Bisoprolol in Hypertension

Frontiers in Cardiovascular Medicine, 2022
PurposeThis study examined the effects of plasma renin activity (PRA), angiotensin II (Ang II) and aldosterone (PAC) concentrations as well as common polymorphisms in the β1-Adrenoceptor gene (ADRB1) and the G-protein α-Subunit (Gαs) protein gene the G ...
Weiwei Zeng, Tanya T. W. Chu, Chung Shun Ho, Clara W. S. Lo, Alan S. L. Chan, Alice P. S. Kong, Brian Tomlinson, Brian Tomlinson, Sze Wa Chan   +8 more
doaj   +1 more source

Regulation of Renin Expression by Β1-Integrin in As4.1 Juxtaglomerular Line Cells

Biomedicines, 2023
(1) Background: Renal dysfunction and hypertension are mutually aggravating factors; however, the details of their interaction remain unclear. In a study using renal tissue from diabetic rats, we found that β1-integrin, a cell-substrate adhesion molecule,
Nobumichi Saito, Masao Toyoda, Masumi Kondo, Makiko Abe, Noriyuki Sanechika, Moritsugu Kimura, Kaichiro Sawada, Masafumi Fukagawa   +7 more
doaj   +1 more source

The Effect of Antihypertensive Medications on Testing for Primary Aldosteronism

Frontiers in Pharmacology, 2021
Primary aldosteronism (PA) is a potentially curable form of secondary hypertension caused by excessive renin-independent aldosterone secretion, leading to increased target organ damage and cardiovascular morbidity and mortality.
Piotr Jędrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong   +3 more
doaj   +1 more source