Results 11 to 20 of about 39,387 (167)

A Rare Cause of Chronic Hypokalemia with Metabolic Alkalosis: Case Report and Differential Diagnosis

Children, 2020
Hypokalemia and metabolic alkalosis can be present in different rare diseases, and the differential diagnosis of these forms is challenging. Apparent mineralcorticoid (AME) excess syndrome is one of these conditions.
Cristina Bertulli, Marguerite Hureaux, Chiara De Mutiis, Andrea Pasini, Detlef Bockenhauer, Rosa Vargas-Poussou, Claudio La Scola   +6 more
doaj   +1 more source

Comparison of the Chemiluminescence Immunoassay LIAISON® with the Radioimmunoassay for Aldosterone and Renin Measurement

Prague Medical Report, 2021
Determination of renin plasma levels is useful in the diagnosis of hypertension and in the therapeutic follow-up of hypertensive patients. Plasmatic concentration of renin decreases in patients with hypertension due to a primary hyperaldosteronism ...
Jana Uhrová, Hana Benáková, Zdislava Vaníčková, Tomáš Zima   +3 more
doaj   +1 more source

Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro [PDF]

, 1992
To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of ...
Kurtz, Armin, Della Bruna, R., R. Della Bruna, Corvol, P., A. Kurtz, F. Pinet, P. Corvol, Pinet, F.   +7 more
core   +1 more source

Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

Cells, 2021
We investigated the expression of components of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations in metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC).
Sam Siljee, Olivia Buchanan, Helen D. Brasch, Nicholas Bockett, Josie Patel, Erin Paterson, Gordon L. Purdie, Paul F. Davis, Tinte Itinteang, Swee T. Tan   +9 more
doaj   +1 more source

Primary aldosteronism and obstructive sleep apnea: What do we know thus far?

Frontiers in Endocrinology, 2022
Both primary aldosteronism and obstructive sleep apnea are well-known causes of hypertension and contribute to increased cardiovascular morbidity and mortality independently.
Huai Heng Loh, Huai Heng Loh, Norlela Sukor   +2 more
doaj   +1 more source

Soluble (Pro)renin Receptor Is Adversely Associated with Indices of Left Ventricular Structure and Function: The African-PREDICT Study

Journal of Cardiovascular Development and Disease, 2022
This study aims to compare soluble (pro)renin receptor [s(P)RR] levels between black and white adults and to explore the associations of left ventricular (LV) structure and function with s(P)RR in the total and ethnicity-stratified groups.
Lebo F. Gafane-Matemane, Ruan Kruger, Johannes M. Van Rooyen, Philimon N. Gona, Aletta E. Schutte   +4 more
doaj   +1 more source

Plasminogen Deficiency and Amiloride Mitigate Angiotensin II–Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Diabetic nephropathy is a common diabetes mellitus complication associated with hypertension, proteinuria, and excretion of urinary plasmin that activates the epithelial sodium channel, ENaC, in vitro. Here we hypothesized that the deletion of
Henrik Andersen, Maria Høj Hansen, Kristian B. Buhl, Mette Stæhr, Ulla G. Friis, Camilla Enggaard, Shanya Supramaniyam, Ida K. Lund, Per Svenningsen, Pernille B. L. Hansen, Boye L. Jensen   +10 more
doaj   +1 more source

Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure.
Estrellita Uijl, Dien Ye, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Hong S. Lu, Alan Daugherty, Ewout J. Hoorn, Paul Nioi, Don Foster, A. H. Jan Danser   +11 more
doaj   +1 more source

Development of a novel murine heart failure model overexpressing human renin and angiotensinogen

FEBS Open Bio, 2020
Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency ...
Tomoya Hara, Takeshi Yamamura, Mirei Murakami‐Asahina, Hirokazu Matsumoto, Michiyasu Takeyama, Ray Kanagawa, Tomoyuki Nishimoto   +6 more
doaj   +1 more source

Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels

Frontiers in Physiology, 2017
Large-conductance calcium-activated potassium channels (BK channels) belong to a family of Ca2+-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body.
Zhen-Ye Zhang, Ling-Ling Qian, Ru-Xing Wang   +2 more
doaj   +1 more source