Results 21 to 30 of about 229,829 (311)

Plasminogen Deficiency and Amiloride Mitigate Angiotensin II–Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Diabetic nephropathy is a common diabetes mellitus complication associated with hypertension, proteinuria, and excretion of urinary plasmin that activates the epithelial sodium channel, ENaC, in vitro. Here we hypothesized that the deletion of
Henrik Andersen, Maria Høj Hansen, Kristian B. Buhl, Mette Stæhr, Ulla G. Friis, Camilla Enggaard, Shanya Supramaniyam, Ida K. Lund, Per Svenningsen, Pernille B. L. Hansen, Boye L. Jensen   +10 more
doaj   +1 more source

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]

, 1990
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S., Kurtz, Armin, Penner, R., Skott, O.   +3 more
core   +1 more source

Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure.
Estrellita Uijl, Dien Ye, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Hong S. Lu, Alan Daugherty, Ewout J. Hoorn, Paul Nioi, Don Foster, A. H. Jan Danser   +11 more
doaj   +1 more source

Development of a novel murine heart failure model overexpressing human renin and angiotensinogen

FEBS Open Bio, 2020
Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency ...
Tomoya Hara, Takeshi Yamamura, Mirei Murakami‐Asahina, Hirokazu Matsumoto, Michiyasu Takeyama, Ray Kanagawa, Tomoyuki Nishimoto   +6 more
doaj   +1 more source

Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels

Frontiers in Physiology, 2017
Large-conductance calcium-activated potassium channels (BK channels) belong to a family of Ca2+-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body.
Zhen-Ye Zhang, Ling-Ling Qian, Ru-Xing Wang   +2 more
doaj   +1 more source

The Effect of Hydroalcoholic Seed Extract of Securigera Securidaca on the Hepatic Renin-Angiotensin System in the Streptozotocin-Induced Diabetic Animal Model

Clinical Diabetology, 2022
BACKGROUND: The aim of the study was to investigate the effect of hydroalcoholic seed extract of Securigera securidaca (S. securidaca) (HESS) on liver local reninangiotensin system (RAS) in streptozotocin-induced diabetic rats.
Bahar Kiani, Shahin Alizadeh-Fanalou, Fatemeh Khomari, Mohammad Babaei, Iraj Alipourfard, Ali Kalantari Hesari, Mohammad Najafi, Ali-Mohammad Sharifi, Elham Bahreini   +8 more
doaj   +1 more source

Variations in Arterial Blood Pressure after Kidney Transplantation [PDF]

, 1973
The course of hypertension within the first 2 months after kidney transplantation was correlated with renal function, plasma renin activity (PRA), and the daily maintenance dose of prednisone in 18 homograft recipients.
CORMAN, JACQUES L, HALGRIMSON, CHARLES G, KATZ, FRED H, LANOIS, BERNARD, PINNGGERA, WULF, POPOVTZER, MORDECAI M, ROBINETTE, JOHN, STARZL, THOMAS E   +7 more
core   +1 more source

Evaluation of Lignan Compound Content and Bioactivity of Raw Omija and Sugared Omija in Serum of Sprague Dawley Rat

Foods, 2019
This study evaluated the lignan contents of raw omija (R) and sugared omija (S), byproducts discarded after the use of raw omija, by HPLC and determined their bioactivity by feeding rats R and S for eight weeks. S retained 63% more lignan than R.
Sung-Hyun Hwa, Su-Jung Yeon, Go-Eun Hong, Won-Young Cho, Ha-Jung Lee, Ji-Han Kim, Chi-Ho Lee   +6 more
doaj   +1 more source

The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis. [PDF]

, 2015
Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption.
Allison, MA, Cushman, M, Jenny, NS, McClelland, RL, Rifkin, D   +4 more
core   +3 more sources

Modulatory Effects of the Kuwanon-Rich Fraction from Mulberry Root Bark on the Renin–Angiotensin System

Foods
In this study, we investigated the anti-hypertensive properties of mulberry products by modulating the renin–angiotensin system (RAS). Comparative analysis showed that the ethyl acetate fractions, particularly from the Cheongil and Daeshim cultivars ...
Ji-Hae Lee, Heon-Woong Kim, So-Ah Kim, Wan-Taek Ju, Seong-Ryul Kim, Hyun-Bok Kim, Ik-Seob Cha, Seong-Wan Kim, Jong-Woo Park, Sang-Kuk Kang   +9 more
doaj   +1 more source