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Protection against isoproterenol-induced cardiac injury by sacubitril/valsartan is associated with upregulation of the alternative renin-angiotensin-aldosterone system pathway [PDF]
Scientific ReportsLong-term stimulation of myocardial beta-receptors by isoproterenol is a well-established model of heart damage and failure. This study investigated the potential interactions of isoproterenol administration with the renin-angiotensin-aldosterone system (
Fedor Simko +7 more
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Updates on the Renin–Angiotensin–Aldosterone System and the Cardiovascular Continuum [PDF]
BiomedicinesThe cardiovascular continuum describes how several cardiovascular risk factors contribute to the development of atherothrombosis, ischemic heart disease, and peripheral arteriopathy, leading to cardiac and renal failure and ultimately death.
Dana Pop +4 more
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Quarterly injectable hormonal contraceptive does not increase the activity of the renin-angiotensin-aldosterone system in women without cardiovascular risk factors [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective: To test the hypothesis that the quarterly injectable contraceptive increases the activity of the renin-angiotensin-aldosterone system. Methods: This was a cross-sectional observational study that included eutrophic, irregularly active women ...
Alice Miranda de Oliveira +6 more
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Advanced Medical Journal, 2023 Background and objectives: Hypertension is an important cardiovascular disease that carries a high rate of mortality and morbidity if not controlled. Significant complications of untreated hypertension include vascular atherosclerosis, chronic kidney ...
Mohammed Hasan Almeshhadani +3 more
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Frontiers in Pharmacology, 2021 Atherosclerosis is considered a disease caused by a chronic inflammation, associated with endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects with atherosclerotic disease.
M. Ekholm, T. Kahan
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The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC
The Journal of Clinical Hypertension, 2022 Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different degrees of ...
Babak Yazdani +9 more
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Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases
Frontiers in Endocrinology, 2023 The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases.
Stepan Gambaryan +4 more
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Zdorovʹe Rebenka, 2015 It is found that only in adolescents with I type left ventricular diastolic dysfunction, there is a significant activation of sympathoadrenal system, and in patients with type II and III, increasing activation of the renin-angiotensin-aldosterone system ...
L.F. Bohmat +3 more
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Frontiers in Physiology, 2017 Large-conductance calcium-activated potassium channels (BK channels) belong to a family of Ca2+-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body.
Zhen-Ye Zhang +2 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundDuring high sodium intake, the renin‐angiotensin‐aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance.
Kelly A. Hyndman +7 more
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