Results 11 to 20 of about 52,295 (246)

The renin-angiotensin-aldosterone system and its suppression [PDF]

Journal of Veterinary Internal Medicine, 2019
Abstract Chronic activation of the renin-angiotensin-aldosterone system (RAAS) promotes and perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic kidney disease. Excessive circulating and tissue angiotensin II (AngII) and aldosterone levels lead to a pro-fibrotic, -inflammatory, and -hypertrophic ...
Marisa K. Ames, Clarke E. Atkins, Bertram Pitt   +2 more
openaire   +4 more sources

The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC

The Journal of Clinical Hypertension, 2022
Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different degrees of ...
Babak Yazdani, Graciela E. Delgado, Marcus E. Kleber, Gökhan Yücel, Faeq Husain‐Syed, Thomas D. Kraemer, Jan Jochims, Jan Leipe, Winfried März, Bernhard K. Krämer   +9 more
doaj   +1 more source

Emergence and evolution of the renin–angiotensin–aldosterone system [PDF]

Journal of Molecular Medicine, 2012
The renin-angiotensin-aldosterone system (RAAS) is not the sole, but perhaps the most important volume regulator in vertebrates. To gain insights into the function and evolution of its components, we conducted a phylogenetic analysis of its main related genes.
Fournier, D., Luft, F.C., Bader, M., Ganten, D., Andrade-Navarro, M.A.   +4 more
openaire   +2 more sources

Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

Frontiers in Endocrinology, 2023
The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases.
Stepan Gambaryan, Sanika Mohagaonkar, Sanika Mohagaonkar, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +4 more
doaj   +1 more source

Features of Neurohumoral Relations in Diastolic Dysfunction of the Heart in Adolescents with Myocardial Pathology

Zdorovʹe Rebenka, 2015
It is found that only in adolescents with I type left ventricular diastolic dysfunction, there is a significant activation of sympathoadrenal system, and in patients with type II and III, increasing activation of the renin-angiotensin-aldosterone system ...
L.F. Bohmat, V.V. Nikonovа, S.R. Tolmachevа, T.S. Vvedenskaia   +3 more
doaj   +1 more source

Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels

Frontiers in Physiology, 2017
Large-conductance calcium-activated potassium channels (BK channels) belong to a family of Ca2+-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body.
Zhen-Ye Zhang, Ling-Ling Qian, Ru-Xing Wang   +2 more
doaj   +1 more source

Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundDuring high sodium intake, the renin‐angiotensin‐aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance.
Kelly A. Hyndman, Elena V. Mironova, Jorge F. Giani, Courtney Dugas, Jessika Collins, Alicia A. McDonough, James D. Stockand, Jennifer S. Pollock   +7 more
doaj   +1 more source

The renin-angiotensin-aldosterone system and fibrinolysis

Journal of the Renin-Angiotensin-Aldosterone System, 2000
Activation of the RAAS has been linked with an increased risk of myocardial infarction and stroke,(1,2,37,38) and recently these beneficial effects have, in part, been attributed to the effects of the RAAS on the fibrinolytic system. Indeed, ACE seems to occupy a central position in modulating the fibrinolytic balance, where an angiotensin II-mediated ...
D C, Felmeden, G Y, Lip
openaire   +2 more sources

Hypertension Management in Patients with Chronic Kidney Disease

Methodist DeBakey Cardiovascular Journal, 2022
Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic
Sean A. Hebert, Hassan N. Ibrahim
doaj   +1 more source

The renin angiotensin aldosterone system and COVID-19

Saudi Pharmaceutical Journal, 2020
The ongoing pandemic has stimulated study of the Renin Angiotensin Aldosterone System (RAAS), and how it can be manipulated to treat COVID-19. Studies are examining whether drugs that act on the RAAS system might be useful to treat COVID-19. COVID-19 and
Hadeel A. Alsufyani, James R. Docherty
doaj   +1 more source