Results 31 to 40 of about 17,321,273 (254)

Disparate effects of calcium channel blockers on pressure dependence of renin secretion and flow in the isolated perfused rat kidney [PDF]

, 1992
Using the model of isolated perfused rat kidneys this study was performed to investigate whether or not voltage-operated calcium channels are essentially involved in the pressure control of renin secretion from the kidneys. At a perfusion pressure of 100
Scholz, Holger, Kurtz, Armin
core   +1 more source

Impaired angiotensin II signaling in septic shock

Annals of Intensive Care
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that this vital homeostatic system, which plays a crucial role in maintaining systemic and renal hemodynamics ...
Adrien Picod, Bruno Garcia, Dirk Van Lier, Peter Pickkers, Antoine Herpain, Alexandre Mebazaa, Feriel Azibani   +6 more
doaj   +1 more source

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Mineralocorticoid-Receptor Blockers Exert Antihypertensive and Renoprotective Effects Independently of the Renin–Angiotensin System

Journal of Pharmacological Sciences, 2010
The role of angiotensin II in mediating hypertension and renal diseases is well documented, and inhibition of the renin–angiotensin–aldosterone system elicits antihypertensive and renoprotective effects.
Akira Nishiyama, Koichi Hasegawa, Suwarni Diah, Hirofumi Hitomi   +3 more
doaj   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia [PDF]

, 2007
Objective Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R).
Hindmarsh, PC, Dattani, MT, Achermann, JC, Metherell, LA, Al-Ali, M, Brain, CE, Alzyoud, M, Clark, AJ, Lin, L, Clark, AJL   +9 more
core   +1 more source

Advances in Unraveling the Role of the Renin-Angiotensin-AldosteroneSystem in Osteoporosis Pathogenesis

Guoji laonian yixue zazhi
The renin-angiotensin-aldosterone system(RAAS) serves as a pivotal regulatory mechanism influencing aldosterone secretion through renin.Functioning as a hormonal cascade,RAAS plays a crucial role in maintaining dynamic homeostasis concerning arterial ...
Zige Liu, Desheng Chen
doaj   +1 more source

RAA System and Exercise Relationship

Türk Spor ve Egzersiz Dergisi, 2019
In this review, it is aimed to discuss the possible interactions between renin-angiotensin-aldosterone system and exercise for health and performance and to present new literature on this subject.
Sadettin Ünsal, Suleyman Patlar
doaj   +1 more source

The role of the angiotensins in the pathogenesis of inflammatory joint disease

Терапевтический архив, 2021
The significant humoral effect of the renin-angiotensin-aldosterone system on the regulation of the cardiovascular system and blood pressure has long been widely known. However, the identification and interpretation of new components of renin-angiotensin-
Andrei V. Gordeev, Elena A. Galushko, Natalia M. Savushkina   +2 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Kenyon, C J, Joel K. Elmquist, Elmquist, Joel K., Flier, Jeffrey S., Jonathan R. Seckl, Yamamoto, H, Yamamoto, Hiroshi, Mullins, J J, John J. Mullins, Shinyama, H, Shinyama, Hiroshi, Masuzaki, H, Nicholas M. Morton, Janice M. Paterson, Paterson, Janice M., Sharp, M G F, Jeffrey S. Flier, Seckl, J R, Sharp, Matthew G. F., Masuzaki, Hiroaki, Paterson, J M, Matthew G.F. Sharp, Seckl, Jonathan R., Hiroshi Yamamoto, Morton, Nicholas M., Stewart Fleming, Elmquist, J K, Morton, N M, Hiroaki Masuzaki, Flier, J S, Mullins, John J., Fleming, S, Hiroshi Shinyama, Fleming, Stewart, Kenyon, Christopher J., Christopher J. Kenyon   +35 more
core   +1 more source