Results 21 to 30 of about 25,081,835 (313)

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

Physiological Reviews, 2017
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body.
R. Santos, W. Sampaio, A. Alzamora, D. Motta-Santos, N. Alenina, M. Bader, M. Campagnole-Santos   +6 more
semanticscholar   +1 more source

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

Nature Reviews Nephrology, 2020
The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-
A. South, L. Tomlinson, Daniel L. Edmonston, S. Hiremath, M. Sparks   +4 more
semanticscholar   +1 more source

Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis?

BMC Nephrology, 2012
Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Fernandez-Fernandez Beatriz, Ortiz Alberto, Gomez-Guerrero Carmen, Barat Antonio, Martín-Cleary Catalina, Egido Jesús   +5 more
doaj   +1 more source

COVID-19, Renin-Angiotensin System and Endothelial Dysfunction

Cells, 2020
The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused by SARS-CoV-2 virus, has posed a serious threat to global public health and caused worldwide social and economic breakdown.
Razie Amraei, N. Rahimi
semanticscholar   +1 more source

The renin–angiotensin system: a possible new target for depression

BMC Medicine, 2017
Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment ...
João Vian, Círia Pereira, Victor Chavarria, Cristiano Köhler, Brendon Stubbs, João Quevedo, Sung-Wan Kim, André F. Carvalho, Michael Berk, Brisa S. Fernandes   +9 more
doaj   +1 more source

Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19

Cardiovascular Research, 2020
Systemic arterial hypertension (referred to as hypertension herein) is a major risk factor of mortality worldwide, and its importance is further emphasized in the context of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
R. Kreutz, E. Algharably, M. Azizi, P. Dobrowolski, T. Guzik, A. Januszewicz, A. Persu, A. Prejbisz, T. Riemer, Ji-Guang Wang, M. Burnier   +10 more
semanticscholar   +1 more source

Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro [PDF]

, 1992
To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of ...
Kurtz, Armin, Della Bruna, R., R. Della Bruna, Corvol, P., A. Kurtz, F. Pinet, P. Corvol, Pinet, F.   +7 more
core   +1 more source

Cardio and neuro protection by renin angiotensin aldosterone system-focus inhibition angiotensin converting enzyme: A systematic review [PDF]

BIO Web of Conferences
One of the incidences of cardiovascular disease is stroke, which is a disease that occurs due to impaired brain function caused by damage to cerebral blood circulation.
Capritasari Rafiastiana, Akrom, Setianto Arif Budi   +2 more
doaj   +1 more source

Counter-regulatory renin–angiotensin system in cardiovascular disease

Nature Reviews Cardiology, 2019
The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I and II — initially thought to be biologically inactive — have key roles in cardiovascular ...
María Paz Ocaranza, Jaime A Riquelme, Lorena García, J. Jalil, M. Chiong, R. Santos, S. Lavandero   +6 more
semanticscholar   +1 more source

Renin-angiotensin system (RAS) blockers and the COVID-19 pandemic: at present there is no evidence to abandon RAS blockers

HYPERTENSION, 2020
During the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19.
A. J. Danser, M. Epstein, D. Batlle
semanticscholar   +1 more source