Results 41 to 50 of about 17,486,344 (255)

Novel Insights into the Cardioprotective Effects of the Peptides of the Counter-Regulatory Renin–Angiotensin System

Biomedicines
Currently, cardiovascular diseases are a major contributor to morbidity and mortality worldwide, having a significant negative impact on both the economy and public health.
Janette Alejandra Gamiño-Gutiérrez, Ivana María Terán-Hernández, Jairo Castellar-Lopez, Wendy Villamizar-Villamizar, Estefanie Osorio-Llanes, Mariali Palacios-Cruz, Wendy Rosales, Aileen Y. Chang, Luis Antonio Díaz-Ariza, María Clara Ospino, Evelyn Mendoza-Torres   +10 more
doaj   +1 more source

Hepatic Mitochondrial Renin-Angiotensin Systems [PDF]

, 2015
Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues ...
Skipworth, JRA
core  

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure [PDF]

, 2008
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear.
Julian Thompson, Nicholas S Hopkinson, Anthony Kehoe, Hopkinson, NS, Humphries, SE, Mostafa Ghanei, Montgomery Hugh, Khoshbaten, A, Hopkinson Nicholas S, Soroush, MR, Hugh Montgomery, Thompson Julian, Hosseini-Khalili, AR, Steve E Humphries, Kehoe, A, Montgomery, H, Ghanei, M, Kehoe Anthony, Hosseini-khalili Ali, Khoshbaten A, A Khoshbaten, Mohammad Reza Soroush, Soroush Mohammad, Thompson, J, Humphries Steve E, Ghanei Mostafa, Ali Reza Hosseini-khalili   +26 more
core   +2 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

THE INFLUENCE OF TISSUE ANGIOTENSINS ON ELEMENTS OF THE CARDIOVASCULAR SYSTEM (LECTURE 2)

Байкальский медицинский журнал
Relevance. One of the main causes of death according to the World Health Organization is cardiovascular diseases. It is well known that dysregulation and/or overexpression of elements of the renin-angiotensin system leads to many negative vascular ...
Liudmila O Gutsol, Irina E Egorova
doaj   +1 more source

Renin-Angiotensin-Aldosterone System in Heart Failure: Focus on Nonclassical Angiotensin Pathways as Novel Upstream Targets Regulating Aldosterone [PDF]

, 2019
Aldosterone plays an important role in the regulation of blood pressure, body fluid, and electrolyte homeostasis. Overactivation of aldosterone/mineralocorticoid receptor (MR) pathway leads to hypertension, atherosclerosis, vascular damage, heart failure,
Mariola Olkowicz, Urszula Tyrankiewicz, Chłopicki, Stefan, Olkowicz, Mariola, Smolenski, Ryszard T., Ryszard T. Smolenski (7951544), Agnieszka Kij, Tyrankiewicz, Urszula, Mariola Olkowicz (3189765), Stefan Chlopicki, Stefan Chlopicki (522371), Urszula Tyrankiewicz (7951541), Mohaissen, Tasnim, Ryszard T. Smolenski, Kij, Agnieszka, Tasnim Mohaissen, Agnieszka Kij (761459), Tasnim Mohaissen (5078378)   +17 more
core   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Hyperkalemia and Renin–Angiotensin–Aldosterone System Inhibitors Dose Therapy in Heart Failure With Reduced Ejection Fraction

Cardiac Failure Review, 2019
Renin–angiotensin–aldosterone system inhibitors (RAASi) are known to improve outcomes in patients who have heart failure with reduced ejection fraction (HFrEF).
Giuseppe MC Rosano, Ilaria Spoletini, Cristiana Vitale, Stefan Agewall   +3 more
doaj   +1 more source

The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19

Frontiers in Pharmacology, 2021
Atherosclerosis is considered a disease caused by a chronic inflammation, associated with endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects with atherosclerotic disease.
M. Ekholm, T. Kahan
doaj   +1 more source

Amiloride enhances the secretion but not the synthesis of renin in renal juxtaglomerular cells [PDF]

, 1991
In this study we have examined a potential role of the sodium/proton exchange system in the regulation of renin secretion. We found that the inhibitors of the Na+/H+ antiport, amiloride (1 mM) and ethylisopropylamiloride (EIPA, 50 microM), led to a 125 ...
Scholz, Holger, Kurtz, Armin, Della Bruna, R., Baier, Wolfgang   +3 more
core   +1 more source