Results 61 to 70 of about 25,081,835 (313)

Interaction of renin–angiotensin system and adenosine monophosphate–activated protein kinase signaling pathway in renal carcinogenesis of uninephrectomized rats

Tumor Biology, 2017
Renin–angiotensin system and adenosine monophosphate–activated protein kinase signaling pathway both play important roles in carcinogenesis, but the interplay of renin–angiotensin system and adenosine monophosphate–activated protein kinase in ...
Ke-Ke Yang, Yi Sui, Hui-Rong Zhou, Hai-Lu Zhao   +3 more
doaj   +1 more source

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

Pharmacological Reviews, 2019
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current therapies for hypertension and related cardiovascular diseases are still ...
Eric L. Barker, Lauren B. Arendse, A. H. J. Danser, M. Poglitsch, R. Touyz, Jr John C. Burnett, C. Llorens-Cortes, Mario R. W. Ehlers, E. Sturrock   +8 more
semanticscholar   +1 more source

Renin-Angiotensin-Aldosterone System in Heart Failure: Focus on Nonclassical Angiotensin Pathways as Novel Upstream Targets Regulating Aldosterone [PDF]

, 2019
Aldosterone plays an important role in the regulation of blood pressure, body fluid, and electrolyte homeostasis. Overactivation of aldosterone/mineralocorticoid receptor (MR) pathway leads to hypertension, atherosclerosis, vascular damage, heart failure,
Mariola Olkowicz, Urszula Tyrankiewicz, Chłopicki, Stefan, Olkowicz, Mariola, Smolenski, Ryszard T., Ryszard T. Smolenski (7951544), Agnieszka Kij, Tyrankiewicz, Urszula, Mariola Olkowicz (3189765), Stefan Chlopicki, Stefan Chlopicki (522371), Urszula Tyrankiewicz (7951541), Mohaissen, Tasnim, Ryszard T. Smolenski, Kij, Agnieszka, Tasnim Mohaissen, Agnieszka Kij (761459), Tasnim Mohaissen (5078378)   +17 more
core   +1 more source

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels

Frontiers in Physiology, 2017
Large-conductance calcium-activated potassium channels (BK channels) belong to a family of Ca2+-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body.
Zhen-Ye Zhang, Ling-Ling Qian, Ru-Xing Wang   +2 more
doaj   +1 more source

Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy.

, 2010
The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Staff, A.C., Luft, F.C., Mueller, D.N., Lydia Hering, Brosnihan, KB, Anne C. Staff, Berthold Huppertz, Katrin Wenzel, Wenzel, K., Brosnihan, K.B., Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Wenzel, K, Huppertz, B, Florian Herse, Staff, AC, Ralf Dechend, Nele Geusens, Cartwright, J.E., K. Bridget Brosnihan, Huppertz, B., Geusens, N., Hering, L, Dominik N. Muller, Dechend, R., Hering, L., Verlohren, S, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
core   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

The renin angiotensin aldosterone system

Pflügers Archiv: European Journal of Physiology
In this review, we will cover (i) the proteolytic cascade of the RAAS, (ii) its regulation by multiple feedback-controlled parameters, and (iii) the major effects of the RAAS.
Hannah Triebel, H. Castrop
semanticscholar   +1 more source

An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology

Journal of Cardiovascular Development and Disease, 2019
In its classical view, the renin angiotensin system (RAS) was defined as an endocrine system involved in blood pressure regulation and body electrolyte balance.
A. Nehme, Fouad A. Zouein, Z. Zayeri, K. Zibara   +3 more
semanticscholar   +1 more source

The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level

, 2007
Introduction. In this study, we investigate the toxic effects of tacrolimus (FK506) on the cardiovascular system at the histopathological level in a rat model and whether these effects can be reversed by the blockade of the renin-angiotensin system (RAS)
TUĞLULAR, ZÜBEYDE SERHAN
core   +1 more source