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Angiotensin receptor antagonists.
Australian family physician, 2000Angiotensin receptor antagonists are a relatively new class of cardiovascular drugs for which the clinical application has not yet been completely defined.This article reviews the pharmacology of the various angiotensin receptor antagonists available in Australia, including their mode of action, side effects and potential drug interactions.Angiotensin ...
W, Wong, L, Howes
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Angiotensin II receptor antagonists - antihypertensive agents
Expert Opinion on Investigational Drugs, 1997Blockade of the renin-angiotensin system (RAS) is now recognised as an effective approach for the treatment of hypertension and congestive heart failure (CHF). Today, it is possible to antagonise the effects of angiotensin II more specifically by blocking its receptors using non-peptide receptor antagonists. These compounds, which at first were used to
M, Burnier, H R, Brunner
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Overview of angiotensin II-receptor antagonists
The American Journal of Cardiology, 1998T renin–angiotensin system is integral to the mechanisms that regulate cardiovascular homeostasis. The renin–angiotensin system has an important role in the pathophysiology of hypertension and heart failure via the vasoconstricting effects of angiotensin II, which sustain elevated blood pressure levels in hypertension and increase afterload in chronic ...
B, Pitt, M A, Konstam
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Angiotensin II receptor antagonists.
Arzneimittel-Forschung, 1993The development of novel non-peptide compounds with high affinity for-angiotensin II (Ang II) receptors has greatly facilitated the subclassification of Ang II receptors into AT1- and AT2-receptor subtypes. Whereas PD 123177 (1-(4-amino-3-methylphenyl)methyl-5-diphenyl-acetyl-4,5,6,7-tetrahydro- 1H-imidazol [4,5-c]pyridine-6-carboxylic acid) is the ...
J C, van Meel +5 more
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Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists
Archives of Otolaryngology–Head & Neck Surgery, 2004The use of angiotensin-converting enzyme inhibitors (ACEIs) has been implicated in many cases of angioedema, but, given the potential mechanism of this complication, it was not expected to be caused by angiotensin II receptor blockers (ARBs). However, in the past few years, scattered reports of angioedema associated with ARBs have appeared in the ...
Dionysios E, Kyrmizakis +7 more
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Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding
European Journal of Pharmacology, 1999Angiotensin II increased the inositol phosphates production (EC50 = 3.4+/-0.7 nM) in Chinese hamster ovary (CHO) cells expressing the cloned human angiotensin AT1 receptor (CHO-AT1 cells). Coincubation with angiotensin AT1 receptor antagonists produced parallel rightward shifts of the concentration-response curve without affecting the maximal response.
Fierens, F L +3 more
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Angiotensin Receptor Antagonists and Cardiovascular Remodeling
1998Angiotensin (Ang) II is one of the key hormones involved in cardiovascular homeostasis. It has potent vasoconstrictor effects and is directly involved in the vascular and cardiac remodeling observed in response to chronic or acute hypertension. Two major Ang II receptor subtypes, AT1 and AT2, have been described, and their roles in vivo and in vitro ...
Sabri, K. +4 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly