Results 51 to 60 of about 175,741,406 (284)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
3D spatial fading correlation for uniform angle of arrival distribution [PDF]
, 2015 We derive a closed-form expression for the spatial fading correlation (SFC) between two arbitrary points in 3D-space for the uniform limited azimuth-elevation angle of arrival probability density function (pdf).
Khalid, Zubair +2 more
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Gaussian Channel Model for Mobile Multipath Environment
EURASIP Journal on Advances in Signal Processing, 2004 A model of an angle-spread source is described, termed the “Gaussian channel model” (GCM). This model is used to represent signals transmitted between a user equipment and a cellular base station.
D. D. N. Bevan +3 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Hardware Design for an Angle of Arrival Positioning System [PDF]
, 2019 Nowadays, there are a variety of different indoor positioning systems employing diverse techniques. Besides inertial navigation, most systems are based on ranging.
Zinke, Adrian +3 more
core +1 more source
NEW TRENDS FOR ANGLE OF ARRIVAL ESTIMATION
Journal of Engineering and Sustainable Development, 2018 The Angle Of Arrival (AOA) estimation of radio signal gained high attention, and effort in the last 20 years, since it is a very important tool for security purposes and for military operations, it is considered as an essential part of Electronic ...
Bassim Sayed Mohammed +1 more
doaj