Results 21 to 30 of about 1,361 (266)

Improved Obstacle Relevancy, Distance, and Angle for Crowds Constrained to Arbitrary Manifolds in 3D Space

, 2012
Recent work has proposed crowd simulation algorithms on arbitrary manifolds in 3D space. These algorithms simulate crowds on far more realistic surfaces than previously possible, including multi-story structures, science fiction scenarios, and habitats ...
Egbert, Parris K., Ricks, Brian C.
core   +1 more source

Electrospun Nanofiber Membranes Incorporating PDMS-Aerogel Superhydrophobic Coating with Enhanced Flux and Improved Antiwettability in Membrane Distillation

, 2019
Electrospun nanofiber membranes (ENMs) have garnered increasing interest due to their controllable nanofiber structure and high void volume fraction properties in membrane distillation (MD).
Jehad Kharraz (6622874), Alicia Kyoungjin An (4370737), Jiaxin Guo (2626273), Alicia Kyoungjin An, Eui-Jong Lee (4370740), Jehad Kharraz, Bhaskar Jyoti Deka (6622871), Eui-Jong Lee, Jiaxin Guo, Bhaskar Jyoti Deka   +9 more
core   +2 more sources

Finite element analysis of the effect of tibial osteotomy on the stress of polyethylene liner in total knee arthroplasty

Journal of Orthopaedic Surgery
Aim To explore the effects of tibial osteotomy varus angle combined with posterior tibial slope (PTS) on the stress of polyethylene liner in total knee arthroplasty (TKA) by building finite element model (FEM). Methods Established the FEM of standard TKA
Lihui Sun, Yu Han, Zheng Jing, Dongbo Li, Jianguo Liu, Dongsong Li   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Wettability of a single carbon fiber

, 2016
Wettability, i.e. contact angle measurement, is a suitable method to characterize the physical bonding of a polymer matrix and reinforcing fibers, but it is highly challenging to measure the capillary force exerted by a probe liquid on a fiber accurately
Fuentes Rojas, Carlos, Seveno, David, Zhang, Dongxing, Van Vuure, Aart Willem, Qiu, Si   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Oxygen Distribution in the Human Eye: Relevance to the Etiology of Open-Angle Glaucoma after Vitrectomy [PDF]

Investigative Opthalmology & Visual Science, 2010
Vitrectomy, when followed by cataract surgery, increases the risk of open-angle glaucoma. This study was conducted in patients to determine whether these procedures are associated with increased exposure of the trabecular meshwork to oxygen.Oxygen distribution was recorded with a fiberoptic probe in patients undergoing surgery for cataract, glaucoma ...
Carla J, Siegfried, Ying-Bo, Shui, Nancy M, Holekamp, Fang, Bai, David C, Beebe   +4 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source