Results 31 to 40 of about 1,361 (266)

Betriebsversuche an einem eTank Modell [PDF]

, 2022
eTanks als saisonale thermische Energiespeicher sind eine vielversprechende Technologie, um die beinahe unendliche Energie der Sonne über das ganze Jahr zu nutzen.
Bernhard, Lukas
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Proline Omega Angle Cis-Trans Isomerization in ArkA12 Using Enhanced Molecular Dynamics

, 2021
ArkA12 is a proline rich intrinsically disordered protein (IDP) region within a larger, more structured, non-tyrosine kinase (ArkA). The disordered region binds to the AbpSH3 domain due to the domain’s high affinity towards PxxP motifs within the ...
Alcantara, Juan
core  

Evaluation of Distal Tibiofibular Interosseous Ligament Angle and Its Relevance in Syndesmosis Fixation

Foot & Ankle Orthopaedics, 2022
Category: Ankle; Basic Sciences/Biologics Introduction/Purpose: The interosseous ligament (IOL) of the ankle, together with the anterior and posterior inferior tibiofibular ligament (ATFL and PITFL), are important structures which ...
Jason Ong, Biju Benjamin, Enhsun Choi, Efstathios Drampalos, Turab Syed   +4 more
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Virtual reality simulation of epiretinal stimulation highlights the relevance of the visual angle in prosthetic vision

Journal of Neural Engineering, 2020
Abstract Objective. Retinal prostheses hold the potential for artificial vision in blind patients suffering from outer retinal dystrophies. The optimal number, density and coverage of the electrodes that a retinal prosthesis should have to provide adequate artificial vision in daily activities ...
Jacob Thomas Thorn, Enrico Migliorini, Diego Ghezzi   +2 more
openaire   +3 more sources

Reliability of clinically relevant 3D foot bone angles from quantitative computed tomography [PDF]

Journal of Foot and Ankle Research, 2013
AbstractBackgroundSurgical treatment and clinical management of foot pathology requires accurate, reliable assessment of foot deformities. Foot and ankle deformities are multi‐planar and therefore difficult to quantify by standard radiographs. Three‐dimensional (3D) imaging modalities have been used to define bone orientations using inertial axes based
Gutekunst, David J, Liu, Lu, Ju, Tao, Prior, Fred W, Sinacore, David R   +4 more
openaire   +2 more sources