Results 71 to 80 of about 72,251 (379)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Angles as Probabilities [PDF]

American Mathematical Monthly, 2009
We use a probabilistic interpretation of solid angles to generalize the well-known fact that the inner angles of a triangle sum to 180 degrees. For the 3-dimensional case, we show that the sum of the solid inner vertex angles of a tetrahedron T, divided by 2*pi, gives the probability that an orthogonal projection of T onto a random 2-plane is a ...
Feldman, David V., Klain, Daniel A.
openaire   +2 more sources

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

A New Angle on Angle Surgery [PDF]

European Ophthalmic Review, 2017
Glaucoma surgery has long relied on ab externo techniques such as augmented trabeculectomy and tube-shunt procedures. While these have excellent potential to lower intraocular pressure (IOP), they are associated with risks, including hypotony, and are therefore conventionally reserved for those with advanced glaucoma or at high risk of visual loss ...
Andrew J Tatham, Mei-Ling Cheng, Rhys Davies   +2 more
openaire   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

T′ AND THE CABIBBO ANGLE

International Journal of Modern Physics A, 2009
The use of the binary tetrahedral group (T′) as flavor symmetry is discussed. I emphasize the CKM quark and PMNS neutrino mixings. I present a novel formula for the Cabibbo angle.
openaire   +2 more sources

Distinct Angles and Angle Chains in Three Dimensions

Discrete Mathematics & Theoretical Computer Science, 2023
In 1946, Erd\H{o}s posed the distinct distance problem, which seeks to find the minimum number of distinct distances between pairs of points selected from any configuration of $n$ points in the plane. The problem has since been explored along with many variants, including ones that extend it into higher dimensions.
Ascoli, Ruben, Betti, Livia, Duke, Jacob Lehmann, Liu, Xuyan, Milgrim, Wyatt, Miller, Steven J., Palsson, Eyvindur A., Acosta, Francisco Romero, Iannuzzelli, Santiago Velazquez   +8 more
openaire   +3 more sources

Welfare of aquatic animals: where things are, where they are going, and what it means for research, aquaculture, recreational angling, and commercial fishing

ICES Journal of Marine Science, 2018
We revisit the evidence attributing sentience-pain-suffering to aquatic animals. The objective is to inform readers of the current state of affairs, to direct attention to where research is needed, and to identify “wicked” questions that are difficult to
H. Browman, S. Cooke, I. Cowx, S. Derbyshire, A. Kasumyan, B. Key, J. D. Rose, A. Schwab, A. Skiftesvik, E. Stevens, C. Watson, R. Arlinghaus   +11 more
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Florida Fishing Guide Requirements Checklist

EDIS, 2020
Guides and captains maintaining vessels used for recreational fishing are an important part of coastal economies, but regulations affecting them can be complicated and may differ depending on several factors, including targeted species ...
Betty Staugler, Ralph Allen, Edward Camp
doaj   +1 more source