Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley +1 more source
Hierarchically Porous Polyaniline Exhibiting Enhanced Pseudocapacitive Property from Copolymerization of Aniline and Tetrakis(4-aminophenyl)methane. [PDF]
Choi J, Yeo KE, Park JW.
europepmc +1 more source
Site‐selective synthesis 4‐suflonylindoles was achieved by a cyclization‐rearrangement strategy by π‐Lewis acidic gold catalysts and the aid of silver cocatalyst. Particularly, the use of 3 equivalents of AgBF4 to SPhosAuCl is crucial for C4‐selective migration of the sulfonyl group.
Itaru Nakamura +2 more
wiley +1 more source
Chemoselective Synthesis of δ-Amino Alcohols from Chiral 1,4-Diols Catalyzed by an NHC-Ir(III) Complex. [PDF]
Silvi E +5 more
europepmc +1 more source
It is a challenge to improve the selectivity of high‐denticity ligands for Mg2+ over Ca2+. We show that in aryl‐alkynyl derivatives of APTRA, electron‐withdrawing substituents lower the binding affinity for Ca2+ more than Mg2+, making the ligand more selective for Mg2+.
Laura L. Duncan +2 more
wiley +1 more source
Elucidating the Multicomponent Reaction Pathway of 2‑Pyrrolidone Synthesis. [PDF]
Dueñas-Deyá A +2 more
europepmc +1 more source
Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger +3 more
wiley +1 more source
Aniline-induced refractory methemoglobinemia in polytrauma: successful management with erythrocytapheresis. [PDF]
Lečbychová K +5 more
europepmc +1 more source
Research frontiers in using biochar for heavy metal remediation. Abstract Heavy metal contamination of water has long been a serious environmental issue. Biochar and biochar‐based composites are emerging as effective and sustainable solutions for heavy metal removal due to their strong adsorption abilities and environmentally friendly nature.
Soumik Chakma +4 more
wiley +1 more source
Metal-Organic Framework/Organocatalyst Combinations as Powerful Multicatalytic Systems for Aerobic Oxidations. [PDF]
Arango-Daza JC +5 more
europepmc +1 more source

