Results 101 to 110 of about 381,835 (335)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Green Care: a Conceptual Framework. A Report of the Working Group on the Health Benefits of Green Care [PDF]

‘Green Care’ is a range of activities that promotes physical and mental health and well-being through contact with nature. It utilises farms, gardens and other outdoor spaces as a therapeutic intervention for vulnerable adults and children.
Berget, B., Braastad, B., Burls, A., Elings, M., Hadden, Y., Haigh, R., Hassink, J., Haubenhofer, D.K.   +7 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Prison Rehabilitation: The Sociological, Physiological, and Psychological Effects of Animal-Assisted Interventions [PDF]

, 2018
This paper examines animal-assisted interventions as a new form of rehabilitation in the prison setting. It focuses specifically on the multiple benefits that this form of therapy/intervention can bring to inmates, such as the reduction in recidivism and
Corleto, Daisy
core   +1 more source

Does owning a pet protect older people against loneliness? [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Pet ownership is thought to make a positive contribution to health, health behaviours and the general well-being of older people. More specifically pet ownership is often
A Gilbey, A Steptoe, AL Podberscek, Ann Bowling, AP Dickens, B Headey, BWJH Penninx, C Victor, C Victor, C Victor, C Victor, C Victor, CB Zhong, Christina Victor, CM Guest, CM Masi, CM Perissinotto, D Melzer, D Russel, DL Wells, E Friedmann, FV Wenz, GC Wenger, H Miltiades, IH Stanley, J Bowlby, J Flaherty, J Hippisley-Coc, J Holt-Lunstad, J McNicholas, J McNicholas, JA Udell, Jitka Pikhartova, JM Siegel, JT Cacioppo, JT Cacioppo, L Andersson, LA Peplau, LB Jennings, M Cattan, M Cattan, M Choi, M Kanamori, M Pinquart, MB Holbrook, MI Wallhagen, MM Herrald, MR Banks, MR Banks, N Savikko, NE Mahon, NM Antonacopoulos, P Demakakos, P Raina, R Hagan, RA Findlay, RA Parslow, RB Olsen, RC Thurston, RF Baumeister, RF Gillum, RS Lazarus, RS Wilson, S Borys, T Fokkema, T Tamura, TF Garrity, The European Pet Food Industry, V Burholt   +68 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Animal-Assisted Therapy: Motives and Rewards [PDF]

, 2014
Animal-assisted therapy is a complimentary therapy utilized in health care to provide goal-directed therapy using dogs. The purpose of this study was to understand what motivates individuals to being animal-assisted volunteering and rewards that ...
Collins, Kailee Victoria
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Animal Assisted Therapy for Children with Autism

International Journal of Child Development and Mental Health, 2017
The inclusion of animals in therapeutic activities, known as animal-assisted therapy, can be used as a treatment practice for people with autism spectrum disorder (ASD).
See Ching Mey
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source