Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Seasonal Variation of Laboratory Animals as a Consideration for Research Reproducibility [PDF]
, 2023 Mark A. Suckow, Noé Tirado-Muñiz
openalex +1 more source
Farm-Animal Welfare, Legislation, and Trade [PDF]
, 2007 The US has among the weakest farm-animal-welfare standards in the developed world. Although improvements in farm-animal welfare are economically feasible, nations and states enacting protective regulation are threatened by competition with cheaper, non ...
Leahy, Cheryl, Matheny, Gaverick
core +1 more source
The political dimension of animal ethics in the context of bioethics: problems of integration and future challenges [PDF]
, 2016 Animal ethics has reached a new phase with the development of animal ethical thinking. Topics and problems previously discussed in terms of moral theories and ethical concepts are now being reformulated in terms of political theory and political action ...
Tirado, Carlos R.
core +2 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model [PDF]
, 2022 Yu-Teng Chang +5 more
openalex +1 more source
Hedgehog signaling in animal development: paradigms and principles.
Genes & Development, 2001 Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental processes in embryonic development.
P. Ingham, A. McMahon
semanticscholar +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
“We Changed Our Nature with Animals”: The Problem of Dehumanization in Heinrich von Kleist’s Works [PDF]
Studia LitterarumThe article examines animalistic motifs in Heinrich von Kleist’s works through the prism of Rousseauian and Kantian philosophy. The comparison of the animal and the human world was one of the most common methods with which Kleist depicted the crisis of ...
Victor A. Finogenov
doaj +1 more source