Results 151 to 160 of about 1,844,801 (289)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Integrating remote international experience and community engagement into course-based animal behavior research. [PDF]

Ecol Evol, 2023
Kay AD, Lager Z, Bhebheza L, Heinen-Kay JL.   +3 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Editorial: Acoustic communication analysis for understanding animal behavior. [PDF]

Front Behav Neurosci, 2022
Bonini SA, Pietropaolo S.
europepmc   +1 more source

5. Social Darwinism Reconsidered

, 1958
Although the contemporary reaction to the implications of evolution was generally one of long-term optimism, an antithetical reaction did exist. Seen in stark terms, evolutionary theories were depressing to those who, on religious or humanitarian grounds,
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold L., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

YORU: Animal behavior detection with object-based approach for real-time closed-loop feedback. [PDF]

Sci Adv
Yamanouchi HM, Takeuchi RF, Chiba N, Hashimoto K, Shimizu T, Osakada F, Tanaka R, Kamikouchi A.   +7 more
europepmc   +1 more source

Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation. [PDF]

Int J Mol Sci, 2022
Zhang H, Wang D, Sun J, Wang Y, Wu S, Wang J.   +5 more
europepmc   +1 more source

エゾヤチネズミ　MYODES　RUFOCANUS　ノ　ヒハンショク　コタイ　ノ　テイオン　カ　デ　ノ　タイエキセイ　メンエキ　ハンノウ　ノ　ヒカク [PDF]

, 2014
Kusumoto, kaori, Laboratory of Animal Behavior Ecology, Faculty of Agriculture, Saga University   +1 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source