Results 91 to 100 of about 13,415,179 (415)

Residues R177 and S178 of the human Na+/H+ antiporter NHA2 are involved in its inhibition by the flavonoid phloretin

FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.
The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova, Martin Kubeš, Tereza Przeczková, Gal Masrati   +3 more
wiley   +1 more source

Ovine leptospirosis in Brazil

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
Leptospirosis is a zoonosis distributed worldwide, endemic mainly in humid subtropical and tropical countries, with epidemic potential. It affects a range of both wild and domestic animals, including sheep, which transport leptospires in their urine and,
SB Lucheis, RS Ferreira Jr.
doaj   +1 more source

Multiple species animal movements: network properties, disease dynamic and the impact of targeted control actions [PDF]

arXiv, 2021
Infectious diseases in livestock are well-known to infect multiple hosts and persist through the combination of within- and between-host transmission pathways. Uncertainty remains about the epidemic consequences of the disease being introduced on farms with more than one susceptible host.
arxiv  

Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins [PDF]

Advanced Understanding of Neurodegenerative Diseases, Edited by Raymond Chuen-Chung Chang, InTech, 2011, ISBN 978-953-307-529-7, Chapter 14, pp. 301-310, 2011
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob diseases, Gerstmann-Str$\ddot{a}$ussler-Scheinker syndrome, Fatal Familial Insomnia, Kuru in humans, scrapie in sheep, bovine spongiform ...
arxiv   +1 more source

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Advocacy for identifying certain animal diseases as “neglected”

PLoS Neglected Tropical Diseases, 2017
According to the World Health Organization (WHO), neglected tropical diseases (NTDs) affect almost 1,000,000,000 people in 149 countries (http://www.who.int/neglected_diseases/diseases/en/).
F. Roger, P. Solano, J. Bouyer, V. Porphyre, D. Berthier, M. Peyre, P. Bonnet   +6 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

An Ensemble of Convolutional Neural Networks to Detect Foliar Diseases in Apple Plants [PDF]

arXiv, 2022
Apple diseases, if not diagnosed early, can lead to massive resource loss and pose a serious threat to humans and animals who consume the infected apples. Hence, it is critical to diagnose these diseases early in order to manage plant health and minimize the risks associated with them.
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Multidisciplinary and Evidence-based Method for Prioritizing Diseases of Food-producing Animals and Zoonoses

Emerging Infectious Diseases, 2012
To prioritize 100 animal diseases and zoonoses in Europe, we used a multicriteria decision-making procedure based on opinions of experts and evidence-based data.
Marie-France Humblet, Sébastien Vandeputte, Adelin Albert, Christiane Gosset, Nathalie Kirschvink, Eric Haubruge, Fabienne Fecher-Bourgeois, Paul-Pierre Pastoret, Claude Saegerman   +8 more
doaj   +1 more source