Results 131 to 140 of about 1,485,253 (263)

A risk-based mutual insurance premium framework for establishing indices of vulnerability to the intentional introduction of transboundary animal diseases. [PDF]

Transbound Emerg Dis, 2022
Levent G, Laine CG, Berquist M, Gonzalez M, Simmons H, Tickel J, Scott HM.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Editorial: Unveiling host-pathogen interactions: insights into animal cellular immunity and novel diagnostics

Frontiers in Cellular and Infection Microbiology
Haojie Wang, Qiang Zhang, Jiangchao Zhao, Changqing Yu, Changyou Xia, He Zhang   +5 more
doaj   +1 more source

The gut-liver axis in animal diseases: roles, mechanisms, and veterinary clinical applications. [PDF]

Front Vet Sci
Peng F, Tang S, Cui Y, Zeng Y.
europepmc   +1 more source

Assessment of animal diseases caused by bacteria resistant to antimicrobials: rabbits. [PDF]

EFSA J, 2021
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Baldinelli F, Alvarez J.   +25 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Transboundary Animal Diseases Associated With Cross-Border Camel Movement. A Systematic Review and Meta-Analysis. [PDF]

Transbound Emerg Dis
Adikwu AA, Emeto TI, Horwood PF, Owolodun OA, Adamu AM, Adegboye OA.   +5 more
europepmc   +1 more source

Modeling the spatial distribution of Culicoides species (Diptera: Ceratopogonidae) as vectors of animal diseases in Ethiopia. [PDF]

Sci Rep, 2022
Fetene E, Teka G, Dejene H, Mandefro D, Teshome T, Temesgen D, Negussie H, Mulatu T, Jaleta MB, Leta S.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Transboundary Animal Diseases and Human Migration: A One Health Perspective on the Balkan Route. [PDF]

Transbound Emerg Dis
Uber E, Angeloni G, Peli A, De Pascali AM, Ingletto L, Scagliarini A.   +5 more
europepmc   +1 more source