Results 131 to 140 of about 5,019,018 (303)

Editorial: Treatment of animal diseases with veterinary phytotherapy. [PDF]

Front Vet Sci, 2023
Nabi F, Shi D, Wu Q, Baloch DM.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Experimental Animal Models in Respiratory Diseases

Düzce Tıp Fakültesi Dergisi
Respiratory diseases are among the leading causes of morbidity and mortality worldwide. Various animal models are used to understand the pathogenesis of these diseases and develop novel therapeutic strategies.
Pınar Yıldız Gülhan
doaj   +1 more source

Description of the Cattle and Small Ruminants Trade Network in Senegal and Implication for the Surveillance of Animal Diseases. [PDF]

Transbound Emerg Dis, 2023
Ciss M, Giacomini A, Diouf MN, Delabouglise A, Mesdour A, Garcia Garcia K, Muñoz F, Cardinale E, Lo M, Gaye AM, Fall M, Ndiaye K, Fall AG, Cetre-Sossah C, Apolloni A.   +14 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ILRAD 1983. Annual report of the International Laboratory for Research on Animal Diseases [PDF]

, 2014
International Laboratory for Research on Animal Diseases
core   +1 more source

Editorial: Regulation of Mitochondrial Function on Animal Diseases. [PDF]

Front Vet Sci, 2022
Zhang H, Chang YF, Liu J.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Public Health Rep [PDF]

On September 11-13, 1957, a Conference on Animal Diseases and Human Health was held in New York City under the joint auspices of the New York Academy of Sciences and the Public Health Service's Communicable Disease Center.The significance of these ...

core