Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU)2016/429): Infection with salmonid alphavirus (SAV). [PDF]
EFSA J, 2023 EFSA Panel on Animal Health and Welfare (AHAW) +28 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The Mexican Animal Identification System: Current Situation, Problems, and Potential [PDF]
Mexico initiated a federal animal identification (ID) system (SINIIGA) in 2003. The program is administered by an agency of the federal Department of Agriculture (SAGARPA) and has been used primarily to support a federal subsidy program for livestock ...
Peel, Derrell S., Ortega, Carlos
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Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) 2016/429): Bacterial kidney disease (BKD). [PDF]
EFSA J, 2023 EFSA Panel on Animal Health and Welfare (AHAW) +28 more
europepmc +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
ILRAD 1982. Annual report of the International Laboratory for Research on Animal Diseases [PDF]
, 2014 International Laboratory for Research on Animal Diseases
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Kansas Pet Animal Act: Policy and Procedures Field Manual, 2009
, 2009 January 1, 2009The Kansas Pet Animal Act requires licensing and inspection of all dog and cat breeders who produce, offer or sell three or more litters during the state fiscal year, pounds and shelters, pet shops, research facilities, distributors, out ...
Kansas Animal Health.
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Optimisation methods for assisting policy decisions on endemic diseases [PDF]
Endemic disease of animals is an economic problem as it deprives humans of scarce resources that might otherwise satisfy human wants. Optimisation methods identify the strategies that minimise this economic problem.
Stott, Alistair W.
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source