Results 171 to 180 of about 5,019,018 (303)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Technologies in Biomarker Discovery for Animal Diseases: Mechanisms, Classification, and Diagnostic Applications. [PDF]

Animals (Basel)
Eman S, Mohai Ud Din R, Zafar MH, Zhang M, Wen X, Ma J, Saleh AA, Husien HM, Wang M, Guo X.   +9 more
europepmc   +1 more source

Assessment of animal diseases caused by bacteria resistant to antimicrobials: Poultry. [PDF]

EFSA J, 2021
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Baldinelli F, Alvarez J.   +25 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Identification of Ethno-veterinary Practices for Animal Diseases in Assosa Zone, Benishangul-Gumuz Region. [PDF]

Vet Med Sci
Yirdaw B.
europepmc   +1 more source

Assessment of animal diseases caused by bacteria resistant to antimicrobials: Horses. [PDF]

EFSA J, 2021
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Sihvonen LH, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Baldinelli F, Alvarez J.   +26 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Manual of rapid diagnosis of animal virus diseases by enzyme immunoassay methods

, 1987
Versiones en inglés y español El diagnóstico de enfermedades virales de los animales, por lo general, se hace aislando el agente etiológico en cultivos celulares.
Devery Pocius, Judy E., Instituto Interamericano de Cooperación para la Agricultura (IICA), Meléndez, Luis V., Dellers, Linda M., Schudel, Alejandro A., Schurig, Gerhardt G.   +5 more
core  

From FAIR to FAIRS: Data security by design for the global burden of animal diseases. [PDF]

Agron J, 2022
Stacey D, Wulff K, Chikhalla N, Bernardo T.   +3 more
europepmc   +1 more source