Results 161 to 170 of about 1,485,253 (263)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Author Correction: Modeling the spatial distribution of Culicoides species (Diptera: Ceratopogonidae) as vectors of animal diseases in Ethiopia. [PDF]

Sci Rep, 2022
Fetene E, Teka G, Dejene H, Mandefro D, Teshome T, Temesgen D, Negussie H, Mulatu T, Jaleta MB, Leta S.   +9 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

One Health Economics approach to prevention and control of zoonotic and animal diseases - considerations for South Africa. [PDF]

One Health Outlook
Mamabolo M, Machalaba C, Zantsi S, Rostal MK, Karesh WB, Thompson PN, Chaminuka P.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Automating updates for scoping reviews on the environmental drivers of human and animal diseases: a comparative analysis of AI methods. [PDF]

Front Artif Intell
Decoupes R, Cataldo C, Busani L, Roche M, Teisseire M.   +4 more
europepmc   +1 more source

Assessment of animal diseases caused by bacteria resistant to antimicrobials: sheep and goats. [PDF]

EFSA J, 2021
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Baldinelli F, Alvarez J.   +25 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A framework for handling uncertainty in a large-scale programme estimating the Global Burden of Animal Diseases. [PDF]

Front Vet Sci
Clough HE, Chaters GL, Havelaar AH, McIntyre KM, Marsh TL, Hughes EC, Jemberu WT, Stacey D, Afonso JS, Gilbert W, Raymond K, Rushton J.   +11 more
europepmc   +1 more source

Assessment of animal diseases caused by bacteria resistant to antimicrobials: kept fish species. [PDF]

EFSA J, 2022
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortazar Schmidt C, Herskin M, Michel V, Miranda Chueca MA, Padalino B, Pasquali P, Roberts HC, Spoolder H, Stahl K, Velarde A, Viltrop A, Winckler C, Dewulf J, Guardabassi L, Hilbert F, Mader R, Romalde JL, Smith P, Baldinelli F, Kohnle L, Alvarez J.   +28 more
europepmc   +1 more source