Results 121 to 130 of about 377,815 (340)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Ethics and animal experimentation: what is debated?
Cadernos de Saúde PúblicaThe purpose of this article is to raise some points for an understanding of the contemporary debate over the ethics of using animals in scientific experiments. We present the various positions from scientific and moral perspectives establishing different
Rita Leal Paixão, Fermin Roland Schramm
doaj +2 more sources
The 3Rs Principle in Animal Experimentation: A Legal Review of the State of the Art in Europe and the Case in Italy. [PDF]
BioTech (Basel), 2021 Maestri E.
europepmc +1 more source
Progress in animal experimentation ethics: a case study from a Brazilian medical school and from the international medical literature [PDF]
, 2012 Edvaldo Luiz Ramalli +3 more
openalex +1 more source
Well-being, work comfort and food security are better than maximizing production in the Amazon [PDF]
, 2008 In the Amazon, slash and burn is the most common technique used by American-Indians, small farmers and even big ranches to transform forests into rural landscapes.
Barbosa, T.M.F. +7 more
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
How many animals are used for SARS-CoV-2 research?: An overview on animal experimentation in pre-clinical and basic research. [PDF]
EMBO Rep, 2021 Schwedhelm P +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source