Results 131 to 140 of about 162,718 (292)

Boyd Group and Animal Experimentation

, 2017
This article is an account of the work of the Boyd Group, an informal grouping of stakeholders on both sides of the debate about animal experimentation formed in Britain in the early 1990s.
Garner, Robert
core  

CONTEMPORARY LEGAL REQUIREMENTS AND ETHICAL PRINCIPLES IN ANIMAL EXPERIMENTATION

Zdravniški Vestnik, 2016
BackgroundThe experiments on animals remain to play an important and yet unreplaceble role in the progress of biomedicine. Therefore, under certain legal conditions, it is morally acceptable to use animals for scientific purposes.
Brigita Perše, Martina Perše
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Ethical-philosophical aspects of human and animal experimentation

, 1994
B
Schafer, Arthureditor, D'Hooge, Reditor, Vermeersch, Etienne801000064422811000064406FC46391C-F0ED-11E1-A9DE-61C894A0A6B4, De Deyn, PPeditor   +3 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Animal experimentation

, 2016
Animal experimentation is a crucial part of medical science. One of the ways to define it is any scientific experiment conducted for research purposes that cause any kind of pain or suffering to animals.
Vrablova, Sofia, Cholakova, Tanya Stefanova, Laz, Alak, Arshad, Naverawaheed   +3 more
core  

Some Problems in Animal Experimentation [PDF]

, 1983
19 pages, 1 article*Some Problems in Animal Experimentation* (Federer, Walter T.) 19 ...
Federer, Walter T., Cornell University. Dept. of Biological Statistics and Computational Biology., Cornell University. Biometrics Unit., Cornell University. Dept. of Biometrics.   +3 more
core  

Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery. [PDF]

BMC Immunol, 2020
Enriquez J, Mims BMD, Trasti S, Furr KL, Grisham MB.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

ANIMAL EXPERIMENTATION

British Journal of Anaesthesia, 1978
openaire   +2 more sources