Results 121 to 130 of about 1,927,178 (242)
Replace, reduce, refine: A review of animal use in Batrachochytrium salamandrivorans research
Conservation Science and PracticeAnimal experimentation is common in wildlife disease research. Understanding the impact of this often‐lethal approach is therefore a critical line of inquiry at the intersection of animal welfare and conservation biology.
Alexandra Boren +2 more
doaj +1 more source
How many animals are used for SARS-CoV-2 research?: An overview on animal experimentation in pre-clinical and basic research. [PDF]
EMBO Rep, 2021 Schwedhelm P +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Is Simulation an Epistemic Substitute for Experimentation? [PDF]
, 2011 It is sometimes said that simulation can serve as epistemic substitute for experimentation. Such a claim might be suggested by the fast-spreading use of computer simulation to investigate phenomena not accessible to experimentation (in astrophysics ...
Peschard, Isabelle
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Regulation of Animal Experimentation
, 1985 The authors review the current controversy between animal activists and the scientific community over the use of animals in research and the regulation of such research.
Overcast, Thomas D., Sales, Bruce D.
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
, 2016 Animal experimentation is a crucial part of medical science. One of the ways to define it is any scientific experiment conducted for research purposes that cause any kind of pain or suffering to animals.
Vrablova, Sofia +3 more
core
, 2017 An essential book for all those who conduct animal-based research or are involved in education and training, as well as regulators, supporters, and opponents alike.
Vaughan Monamy
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source