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Animal Models of Hemophilia [PDF]

, 2012
The X-linked bleeding disorder hemophilia is caused by mutations in coagulation factor VIII (hemophilia A) or factor IX (hemophilia B). Unless prophylactic treatment is provided, patients with severe disease (less than 1% clotting activity) typically experience frequent spontaneous bleeds.
Denise E, Sabatino, Timothy C, Nichols, Elizabeth, Merricks, Dwight A, Bellinger, Roland W, Herzog, Paul E, Monahan   +5 more
openaire   +3 more sources

Generation of rat offspring from ovarian oocytes by xenotransplantation

Scientific Reports
The idea of utilizing unused oocytes present in the ovaries has been tested in various ways to produce offspring. However, only a limited number of studies succeeded in offspring generation.
Hiroaki Taketsuru, Runa Hirayama, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Manabu Abe, Kenji Sakimura   +6 more
doaj   +1 more source

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

Nature Communications, 2017
Tumor associated macrophages (TAMs) promote cancer progression. Here, the author show that caspase-1 promotes TAMs differentiation by attenuating medium-chain acyl-CoA dehydrogenase activity and that inhibition of this axis results in suppression of ...
Zhiyuan Niu, Qian Shi, Wenlong Zhang, Yuxin Shu, Nanfei Yang, Bing Chen, Qingsong Wang, Xuyang Zhao, Jiajia Chen, Nan Cheng, Xiujing Feng, Zichun Hua, Jianguo Ji, Pingping Shen   +13 more
doaj   +1 more source

Gut microbiota affects obesity susceptibility in mice through gut metabolites

Frontiers in Microbiology
IntroductionIt is well-known that different populations and animals, even experimental animals with the same rearing conditions, differ in their susceptibility to obesity.
Yuhang Wen, Yuhang Wen, Yadan Luo, Yadan Luo, Hao Qiu, Hao Qiu, Baoting Chen, Baoting Chen, Jingrong Huang, Jingrong Huang, Shuya Lv, Shuya Lv, Yan Wang, Yan Wang, Jiabi Li, Jiabi Li, Lingling Tao, Lingling Tao, Bailin Yang, Bailin Yang, Ke Li, Ke Li, Lvqin He, Lvqin He, Manli He, Manli He, Qian Yang, Qian Yang, Zehui Yu, Zehui Yu, Wudian Xiao, Wudian Xiao, Mingde Zhao, Mingde Zhao, Xiaoxia Zou, Ruilin Lu, Congwei Gu, Congwei Gu   +37 more
doaj   +1 more source

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

Molecules, 2019
Soy isoflavones (SIF) are biologically active compounds of non-steroidal and phenolic properties that are richly present in soybeans, which can reduce the body weight and blood lipids of obese animals.
Qihui Luo, Yifan Li, Chao Huang, Dongjing Cheng, Wenjing Ma, Yu Xia, Wentao Liu, Zhengli Chen   +7 more
doaj   +1 more source

CGA alleviates LPS-induced inflammation and milk fat reduction in BMECs through the NF-κB signaling pathway

Heliyon
Mastitis is an easy clinical disease in dairy cows, which seriously affects the milk yield and quality of dairy cows. Chlorogenic acid (CGA), a polyphenolic substance, is abundant in Eucommia ulmoides leaves and has anti-inflammatory and anti-oxidative ...
Chen-Chen Lyu, Xing-Yu Ji, Hao-Yu Che, Yu Meng, Hong-Yu Wu, Jia-Bao Zhang, Yong-Hong Zhang, Bao Yuan   +7 more
doaj   +1 more source

Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit

EMBO Molecular Medicine, 2016
Upon adaption of skeletal muscle to physiological and pathophysiological stimuli, muscle fiber type and mitochondrial function are coordinately regulated.
Jing Liu, Xijun Liang, Danxia Zhou, Ling Lai, Liwei Xiao, Lin Liu, Tingting Fu, Yan Kong, Qian Zhou, Rick B Vega, Min‐Sheng Zhu, Daniel P Kelly, Xiang Gao, Zhenji Gan   +13 more
doaj   +1 more source

PGC-1α-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice

Antioxidants
High-fat-diet (HFD)-induced obesity parallels hypothalamic inflammation and oxidative stress, but the correlations between them are not well-defined. Here, with mouse models targeting the antioxidant gene LanCL1 in the hypothalamus, we demonstrate that ...
Shuai Shi, Jichen Wang, Huan Gong, Xiaohua Huang, Bin Mu, Xiangyu Cheng, Bin Feng, Lanlan Jia, Qihui Luo, Wentao Liu, Zhengli Chen, Chao Huang   +11 more
doaj   +1 more source

A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model

Biology Open, 2016
The low-density lipoprotein receptor (LDLR) plays a critical role in the liver for the clearance of plasma low-density lipoprotein (LDL). Its deficiency causes hypercholesterolemia in many models.
Hong Yu Wang, Chao Quan, Chunxiu Hu, Bingxian Xie, Yinan Du, Liang Chen, Wei Yang, Liu Yang, Qiaoli Chen, Bin Shen, Bian Hu, Zhihong Zheng, Haibo Zhu, Xingxu Huang, Guowang Xu, Shuai Chen   +15 more
doaj   +1 more source

Endogenous controls of gene expression in N-methyl-N-nitrosourea-induced T-cell lymphoma in p53-deficient mice

BMC Cancer, 2017
Background Real-time polymerase chain reaction (PCR) has become an increasingly important technique for gene expression profiling because it can provide insights into complex biological and pathological processes and be used to predict disease or ...
Xi Wu, Susu Liu, Jianjun Lyu, Shuya Zhou, Yanwei Yang, Chenfei Wang, Wenda Gu, Qin Zuo, Baowen Li, Changfa Fan   +9 more
doaj   +1 more source