Results 21 to 30 of about 2,220,916 (268)

A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption

EBioMedicine, 2020
Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou, Jingwen Pei, Jianfeng Lan, Hong Sang, Hongjuan Chen, Haoliang Yuan, Di Wu, Yuanyuan Zhang, Yufang Wang, Dingyu Wang, Yujie Zou, Di Chen, Jianan Ren, Xiang Gao, Zhaoyu Lin   +14 more
doaj   +1 more source

Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro

BMC Cancer, 2023
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu, Yiyan Yang, Junting Yang, Lanfei Xiao, Xiaotang Wang, Litao Qin, Jiping Gao, Ruijing Xuan, Xiaofen Wu, Zhaoyang Chen, Rui Sun, Guohua Song   +11 more
doaj   +1 more source

6-Gingerol Improves In Vitro Porcine Embryo Development by Reducing Oxidative Stress

Animals, 2023
6-Gingerol, the main active ingredient in ginger, exhibits a variety of biological activities, such as antioxidant, anti-inflammatory, and anticancer activities, and can affect cell development.
Wenjie Yu, Yanxia Peng, Xinyue Peng, Ze Li, Chang Liu, Liu Yang, Yan Gao, Shuang Liang, Bao Yuan, Chengzhen Chen, Nam-hyung Kim, Hao Jiang, Jiabao Zhang   +12 more
doaj   +1 more source

Improvement of animal welfare by strategic analysis and logistic optimisation of animal slaughter transportation

, 2016
The transportation of animals to slaughterhouses is a major welfare concern. The number of slaughterhouses has decreased over time in Europe due to centralisation.
Wennergren, U.,, Jonsson, A.,, Algers, B.,, Håkansson, Nina,, Hakansson, N.,, Wennergren, Uno,, Flisberg, P.,, Jonsson, Annie,, Rönnqvist, M.,   +8 more
core   +1 more source

The molecular basis of the genesis of basal tone in internal anal sphincter

Nature Communications, 2016
The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2 ...
Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, Min-Sheng Zhu   +19 more
doaj   +1 more source

Human norovirus animal model essential for vaccine development

, 2021
Human noroviruses are the most common cause of acute gastroenteritis and represent an incredibly high burden on the healthcare sector. Currently no vaccines or drugs exist to prevent or treat the disease.
Ramesh, Ashwin, Parreño, Viviana, Yuan, Lijuan   +2 more
core  

Zebrafish as an alternative animal model in human and animal vaccination research

, 2020
Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies.
Grejo Setti, Princia, Bailone, Ricardo Lacava [UNESP], Borra, Ricardo Carneiro, Roca, Roberto De Oliveira [UNESP], De Aguiar, Luis Kluwe, Fukushima, Hirla Costa Silva, Ventura Fernandes, Bianca Helena, Correa, Tatiana, Janke, Helena   +8 more
core   +1 more source

HAX1 inhibits apoptosis and promotes maturation of neutrophils

Cell Communication and Signaling
As the diverse functions of neutrophils continue to be uncovered, elucidating the molecular mechanisms that regulate their differentiation, development, and apoptosis has become crucial for overcoming limitations in the treatment of neutrophil-related ...
Hanwei Yue, Guiying Shi, Jiaming Tang, Xinyue Li, Lin Bai   +4 more
doaj   +1 more source

The 2020 Five Domains Model: Including Human–Animal Interactions in Assessments of Animal Welfare

, 2020
Throughout its 25-year history, the Five Domains Model for animal welfare assessment has been regularly updated to include at each stage the latest authenticated developments in animal welfare science thinking.
Paul D. McGreevy, Bidda Jones, Katherine E. Littlewood, Ngaio J. Beausoleil, Andrew N. McLean, Cristina Wilkins, David J. Mellor   +6 more
core   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source