Results 21 to 30 of about 2,221,657 (315)

The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration

Journal of Neuroinflammation, 2019
Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu, Yun Gao, Ru Yang, Tian Guan, Jau-Shyong Hong, Hui-Ming Gao   +5 more
doaj   +1 more source

Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation

Cell Discovery, 2022
Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou, Qiaoli Chen, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu, Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan, Shuai Chen   +10 more
doaj   +1 more source

Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells

Cell Reports, 2018
Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang, Wukui Zhao, Congcong Wang, Yaru Zhu, Mengjie Liu, Huan Tong, Yin Xia, Qing Jiang, Jinzhong Qin   +8 more
doaj   +1 more source

204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析

Journal of Diabetes, 2022
Background High fasting plasma glucose (HFPG) is the leading risk factor contributing to the increase of stroke burden in the past three decades. However, the global distribution of stroke burden specifically attributable to HFPG was not studied in depth.
Yang Liu, Wenxin Wang, Xuewei Huang, Xingyuan Zhang, Lijin Lin, Juan‐Juan Qin, Fang Lei, Jingjing Cai, Bo Cheng   +8 more
doaj   +1 more source

ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans

Nature Communications, 2023
Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from
Zi Wang, Lina Zou, Yiyan Zhang, Mengnan Zhu, Shuxian Zhang, Di Wu, Jianfeng Lan, Xiao Zang, Qi Wang, Hanxin Zhang, Zixing Wu, Huanhu Zhu, Di Chen   +12 more
doaj   +1 more source

Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro

BMC Cancer, 2023
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu, Yiyan Yang, Junting Yang, Lanfei Xiao, Xiaotang Wang, Litao Qin, Jiping Gao, Ruijing Xuan, Xiaofen Wu, Zhaoyang Chen, Rui Sun, Guohua Song   +11 more
doaj   +1 more source

A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption

EBioMedicine, 2020
Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou, Jingwen Pei, Jianfeng Lan, Hong Sang, Hongjuan Chen, Haoliang Yuan, Di Wu, Yuanyuan Zhang, Yufang Wang, Dingyu Wang, Yujie Zou, Di Chen, Jianan Ren, Xiang Gao, Zhaoyu Lin   +14 more
doaj   +1 more source

Animal Models in Osteosarcoma [PDF]

Frontiers in Oncology, 2014
Osteosarcoma (OS) is the most common non-hematologic primary tumor of bone in children and adults. High-dose cytotoxic chemotherapy and surgical resection have improved prognosis, with long-term survival for non-metastatic disease approaching 70%. However, most OS tumors are high grade and tend to rapidly develop pulmonary metastases.
Guijarro, Maria V., Ghivizzani, Steven C., Gibbs, C. Parker   +2 more
openaire   +3 more sources

Animal-level variables used in regression model. [PDF]

, 2018
Animal-level variables used in regression model.
Debby Lipschutz-Powell (153720), Andrew P. Mitchell (114903), Andrew J. K. Conlan (114901), Trevelyan J. McKinley (113745), James L. N. Wood (111001)   +4 more
core   +1 more source

The molecular basis of the genesis of basal tone in internal anal sphincter

Nature Communications, 2016
The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2 ...
Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, Min-Sheng Zhu   +19 more
doaj   +1 more source