Results 21 to 30 of about 3,972,530 (300)
Power-law versus exponential distributions of animal group sizes [PDF]
, 2003 There has been some confusion concerning the animal group-size: an exponential distribution was deduced by maximizing the entropy; lognormal distributions were practically used; a power-law decay with exponent {3/2} was proposed in physical analogy to ...
Anderson +24 more
core +1 more source
The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
Journal of Neuroinflammation, 2019 Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu +5 more
doaj +1 more source
Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation
Cell Discovery, 2022 Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou +10 more
doaj +1 more source
Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells
Cell Reports, 2018 Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang +8 more
doaj +1 more source
BMC Cancer, 2023 Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu +11 more
doaj +1 more source
Using Machine Learning to Predict Swine Movements within a Regional Program to Improve Control of Infectious Diseases in the US. [PDF]
, 2017 Between-farm animal movement is one of the most important factors influencing the spread of infectious diseases in food animals, including in the US swine industry.
Jarvis, Lovell S +4 more
core +1 more source
EBioMedicine, 2020 Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou +14 more
doaj +1 more source
Modelling Farm Animal Welfare [PDF]
Animals, 2013 The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research.
Lisa Collins, Cherie E. Part
openaire +5 more sources
Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM. [PDF]
, 2017 Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an ...
Freeman, Lisa M +4 more
core +2 more sources
The molecular basis of the genesis of basal tone in internal anal sphincter
Nature Communications, 2016 The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2 ...
Cheng-Hai Zhang +19 more
doaj +1 more source