Results 171 to 180 of about 344,168 (253)

The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies. [PDF]

Sci Rep, 2013
Macrì S, Ceci C, Altabella L, Canese R, Laviola G.   +4 more
europepmc   +1 more source

Analgesia in Experimental Animals

Journal of Investigative Surgery, 1999
openaire   +3 more sources

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Are we going to allow the last nail on the coffin of animal experimentation to be nailed?

J Pharmacol Pharmacother, 2012
Gitanjali B.
europepmc   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Retraction: Effects of UCP4 on the proliferation and apoptosis of chondrocytes: Its possible involvement and regulation in osteoarthritis. [PDF]

PLoS One
PLOS ONE Editors.
europepmc   +1 more source

Alternatives to animal experimentation for hormonal compounds research. [PDF]

Genes Nutr, 2009
Penza M, Jeremic M, Montani C, Unkila M, Caimi L, Mazzoleni G, Di Lorenzo D.   +6 more
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Evaluation of the effect of metal stents on dose perturbation in the carbon beam irradiation field

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Propose Carbon ion therapy is indicated for cases in which stents have been inserted, such as bile ducts, but the effect of metal stents on carbon ion therapy is unclear. In this study, the dose perturbation of carbon ion therapy caused by metallic bile duct stents was evaluated by dosimetry. Materials and methods Five different types of metal
Yuya Miyasaka, Tetsuya Ishizawa, Yoshihito Nawa, Hikaru Souda, Shohei Kawashiro, Hongbo Chai, Miyu Ishizawa, Hiraku Sato, Takeo Iwai   +8 more
wiley   +1 more source