Results 211 to 220 of about 3,677,147 (314)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A Thematic Analysis of Motivators and Barriers to Antimicrobial Resistance Interventions With Farmers and Animal Health Professionals in Nigeria. [PDF]

Vet Med Int
Jacobsen ABJE, Ogden J, Wakawa A, Ekiri AB.   +3 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Antimicrobial Consumption and Utilisation in Zambia: Results from the Analysis of National Data for the Human and Animal Health Sectors. [PDF]

Antibiotics (Basel)
Mudenda S, Chizimu JY, Daka V, Kasanga M, Mufwambi W, Mwangilwa K, Hangoma J, Gardner P, Chileshe C, Mudenda NB, Sinyawa T, Siame A, Hadunka M, Simwinji FM, Kaunda K, Chibi M, Muhimba Z, Jere E, Siyanga M, Lisulo P, Masaninga F, Mukale S, Bambala A, Shawa M, Chileshe C, Chibwe B, Mukuma M, Phiri BSJ, Mainda G, Suzuki Y, Goma F, Muma JB, Chilengi R.   +32 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Development of the Zambian Standard Treatment Guidelines in the Animal Health Sector: A Key Step in Advancing Antimicrobial Stewardship. [PDF]

Antibiotics (Basel)
Chileshe C, Goma F, Mudenda NB, Mudenda S, Sinyawa T, Hadunka M, Mainda G, Muyamwa N, Mubamba C, Mtui Malamsha NJ, Filippini SP, Kasanga M, Daka V, Mufwambi W, Siame A, Kalungia AC, Muhimba Z, Mukuma M, Mwadesta SD, O-Tipo S, Hangoma J, Muma JB, Chizimu JY, Maseka C, Chilengi R.   +24 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Bovine mastitis epidemiology: Prevalence, risk factors, control program gaps and biosecurity recommendations to improve animal health in the Rwandan smallholder dairy farms. [PDF]

PLoS One
Iraguha B, Gasana MN, Mpatswenumugabo JPM.   +2 more
europepmc   +1 more source