Results 131 to 140 of about 521,393 (302)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Challenges and opportunities for data integration to improve estimation of migratory connectivity

Methods in Ecology and Evolution
Understanding migratory connectivity, or the linkage of populations between seasons, is critical for effective conservation and management of migratory wildlife.
Jeffrey A. Hostetler, Emily B. Cohen, Christen M. Bossu, Amy L. Scarpignato, Kristen Ruegg, Andrea Contina, Clark S. Rushing, Michael T. Hallworth   +7 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Genotype But Not Body Shape Predicts River Migration Success in Atlantic Salmon

Ecology and Evolution
Migratory species typically undertake demanding long‐distance journeys, across different habitat types during which they are exposed to multiple natural and anthropogenic stressors.
Paolo Moccetti, Jonathan D. Bolland, Colin E. Adams, Jessica R. Rodger, Hannele M. Honkanen, Matthew Newton, Angus J. Lothian, Andy D. Nunn, Domino A. Joyce   +8 more
doaj   +1 more source

Developmental stage shapes the realized energy landscape for a flight specialist

eLife
The heterogeneity of the physical environment determines the cost of transport for animals, shaping their energy landscape. Animals respond to this energy landscape by adjusting their distribution and movement to maximize gains and reduce costs.
Elham Nourani, Louise Faure, Hester Brønnvik, Martina Scacco, Enrico Bassi, Wolfgang Fiedler, Martin U Grüebler, Julia S Hatzl, David Jenny, Andrea Roverselli, Petra Sumasgutner, Matthias Tschumi, Martin Wikelski, Kamran Safi   +13 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Correction to: Avian Immunome DB: an example of a user‑friendly interface for extracting genetic information

BMC Bioinformatics, 2021
Ralf C. Mueller, Nicolai Mallig, Jacqueline Smith, Lél Eöry, Richard I. Kuo, Robert H. S. Kraus   +5 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

IAPs on the move : role of inhibitors of apoptosis proteins in cell migration

, 2013
Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecules in the regulation of tumor cell
Oberoi-Khanuja, Tripat Kaur, Murali, Arun, Rajalingam, Krishnaraj   +2 more
core   +1 more source