Results 201 to 210 of about 27,577,089 (399)
CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceDevelopment and Validation of an Acute Large Animal Model for Type A Aortic Dissection. [PDF]
J Cardiovasc Dev DisDeniz E, Marsen S, Helms F, Krüger H, Arima N, Hanke J, Merzah AS, Al-Hasan-Al-Saegh S, Knigge S, Alhowaizy S, Meyer T, Hinkel R, Arar M, Popov AF, Dogan G, Schmack B, Weymann A, Ruhparwar A, Mohamed-Glüer SA, Schmitto JD. +19 moreeuropepmc +1 more sourceReviewer #2 (Public Review): Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
, 2023 Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Takamiya Yoshihiro, Tanaka Mika, Ihara Masafumi, Shibutani Mihiro, Izuho Hatada, Kei Hori, Mikio Hoshino, Nakao Akito, Yasuo Mori, Shigeo Okabe, Matsushita Masayuki, Urbach Anja, Yuta Katayama, Matsumoto Akinobu, Nakayama Keiichi I., Katori Shota, Takuya Sato, Takuji Iwasato, Nakamura Haruko, Goshima Yoshio, Raveau Matthieu, Tetsuya Tatsukawa, Yamakawa Kazuhiro, Takahashi Noriko, Kasai Haruo, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Darwish Mohamed, Hirofumi Nishizono, Takao Keizo, Sapkota Kiran, Nakazawa Kazutoshi, Tsuyoshi Takagi, Fujisawa Haruki, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Hannah Nanette Deneen, Meltzer Herbert Y., Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Kunugi Hiroshi, Huang Freesia L., Hayata-Takano Atsuko, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Graef Isabella A., Crabtree Gerald R., Asaoka Nozomi, Hikari Hatakama, Kaneko Shuji, Kohno Takao, Hattori Mitsuharu, Hoshiba Yoshio, Miyake Ryuhei, Obi-Nagata Kisho, Hayashi-Takagi Akiko, Becker Léa J., Yalcin Ipek, Hagino Yoko, Kotajima-Murakami Hiroko, Yuki Moriya, Ikeda Kazutaka, Kim Hyopil, Kaang Bong-Kiun, Otabi Hikari, Yuta Yoshida, Atsushi Toyoda, Komiyama Noboru H., Grant Seth G. N., Ida‐Eto Michiru, Masaaki Narita, Matsumoto Ken-ichi, Emiko Okuda‐Ashitaka, Ohmori Iori, Tadayuki Shimada, Yamagata Kanato, Ageta Hiroshi, Tsuchida Kunihiro, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Fukasawa Motoaki, Usuda Nobuteru, Katano Tayo, Tanaka Teruyuki, Yoshihiro Yoshihara, Michihiro Igarashi +99 moreopenalex +1 more sourceA large animal model of spinal muscular atrophy and correction of phenotype
Annals of Neurology, 2015 S. Duqué, W. Arnold, P. Odermatt, Xiaohui Li, P. Porensky, L. Schmelzer, K. Meyer, S. Kolb, D. Schümperli, B. Kaspar, A. Burghes +10 moresemanticscholar +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more source
