Results 201 to 210 of about 27,467,558 (397)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury

open access: green, 2022
Panagiotis Kratimenos   +6 more
openalex   +1 more source

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

open access: yesNeuron, 2009
D. David   +15 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Author Correction: The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis

open access: yesNature Communications, 2022
Sangsang Zhu   +14 more
doaj   +1 more source

Establishment of Subtrochanteric Fracture in Pre-Clinical Animal Model. [PDF]

open access: yesOrthop Surg
Palanisamy P   +6 more
europepmc   +1 more source

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