Results 191 to 200 of about 2,034,258 (266)

Birds may represent a useful animal model for studying human mental disorders. [PDF]

Acta Neuropsychiatr
Loonen AJM.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Anti-inflammatory effects of curcumin carbon dots in an animal model of demyelination induced by lysolecithin. [PDF]

Nanoscale Adv
DaeiRezaei L, Parandavar E, Javan M, Nikkhah M.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Abnormal behaviors and glial responses in an animal model of tau pathology. [PDF]

Mol Brain
Liu Y, Sobue A, Sahara N, Isobe M, Tanaka R, Zhu Y, Zhu W, Matsuzaki T, Yamanaka K, Yamada K, Mizoguchi H.   +10 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Key refinements to a large animal model for measurement of real-time lymphatic transport. [PDF]

BMC Med Imaging
Fanning JE, Bustos V, Jang P, Ser J, Kim E, Kinney J, Yamashita A, Choi HS, Singhal D.   +8 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Disruption of afferent neural circuits leads to arrhythmia in the animal model of hereditary sensory and autonomic neuropathy 6. [PDF]

Front Neural Circuits
Yoshioka N, Kurose M, Tainaka K, Ichiki T, Tsuneoka Y, Funato H, Ueno M, Ohshima H, Kageyama I, Takebayashi H.   +9 more
europepmc   +1 more source