Results 171 to 180 of about 2,220,916 (268)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Novel Potential Markers of Metabolic Dysfunction–Associated Steatohepatitis Prone to Hepatocellular Carcinoma

Canadian Journal of Gastroenterology and Hepatology
Chen Ling, Yuya Wang, Susu Liu, Guitao Huo, Yanwei Yang, Nan Xu, Hong Wang, Haoyang Zhao, Zeqiang Zhang, Rui Fu, Yuwei Zhao, Changfa Fan   +11 more
doaj   +1 more source

Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus. [PDF]

Sci Rep
Eloranta ML, Nygren P, Larsson R, Loskog A, Woodworth N, Hultqvist M, Svensson R, Gravenfors Y, Rönnblom L, Fryknäs M.   +9 more
europepmc   +1 more source

ECONOMIC BENEFITS OF ANIMAL TRACING IN THE CATTLE PRODUCTION SECTOR

One of the options to prepare for a potential outbreak of an infectious livestock disease is to initiate an animal tracking system, which would provide information on animal movements and facilitate disease management.
Elbakidze, Levan
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Behavioural susceptibility to environmental influences in obesity- evidence from a companion animal model. [PDF]

BMC Vet Res
Morros-Nuevo A, Salt C, Pavey J, F Wainwright J, Dittmann M, Keep B, Wallis NJ, Raffan E.   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal model. [PDF]

PLoS One
Ortega-Fimbres O, Ríos-Carrillo R, Gaspar-Martínez E, Ruiz-Acosta P, Regalado M, Luna-Munguía H, Ramírez-Manzanares A, Concha L.   +7 more
europepmc   +1 more source

Impacts of labour on interactions between economics and animal welfare in extensive sheep farms

This study quantified interactions between animal welfare and farm profitability in British extensive sheep farming systems. Qualitative welfare assessment methodology was used to assess welfare from the animal's perspective in 20 commercial extensive ...
Goddard, Pete, Erhard, H.W., Vosough Ahmadi, Bouda, Waterhouse, A., Dwyer, Cathy M., Ringrose, Sian, Kupiec-Teahan, Beata, Phillips, Kate, Milne, Catherine E., Stott, Alistair W., Morgan-Davies, Claire   +10 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source