Results 151 to 160 of about 2,220,916 (268)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Molnupiravir is effective against hepatitis E virus infection in an animal model. [PDF]

Hepatol Commun
Wu S, Chew NF, Ma X, Situ J, Shun EH, Li C, Ip JD, Ho SS, Zhang AJ, Tsoi JY, Chan WM, Ma W, Liang Y, Mao W, Chen KWY, Yin F, To KK, Yuan S, Chan JF, Zhu L, Huang Y, Sridhar S.   +21 more
europepmc   +1 more source

Estimating abundance of rare, small mammals: A case study of the Key Largo woodrat (Neotoma floridana smalli)

, 2011
Estimates of animal abundance or density are fundamental quantities in ecology and conservation, but for many species such as rare, small mammals, obtaining robust estimates is problematic.
Potts, Joanne M.
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Choosing the right animal model for sarcoma research. [PDF]

Cell Mol Life Sci
Remiszewski P, Siedlecki E, Wełniak-Kamińska M, Mikula M, Czarnecka A.   +4 more
europepmc   +1 more source

Valuing Animal Welfare with Choice Experiments: An Application to Swedish Pig Production

In this paper, the demand for animal welfare attributes when buying pork fillet is investigated among Swedish respondents. More specifically, the coefficients of an indirect utility function and willingness to pay for animal welfare attributes are ...
Liljenstolpe, Carolina
core  

GM 03. Heritability of scrotal circumference adjusted and unadjusted for body weigth in Nellore bulls using uni and bivariate animal model

, 2005
Mixed model methodology under uni and bivariate animal models were used to estimated genetic parameters of scrotal circumference (SC) adjusted (h2AJ) and unadjusted (h2NAJ) by body weigth (BW), of 875 Nelore bulls.
Quirino, Celia Raquel, Bergmann, Jose Aurelio   +1 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Author Correction: The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis

Nature Communications, 2022
Sangsang Zhu, Chao Quan, Ruizhen Wang, Derong Liang, Shu Su, Ping Rong, Kun Zhou, Xinyu Yang, Qiaoli Chen, Min Li, Qian Du, Jingzi Zhang, Lei Fang, Hong-Yu Wang, Shuai Chen   +14 more
doaj   +1 more source

OLD DOG - Validating the dog as an animal model for human aging studies. [PDF]

J Frailty Aging
Zemko P, Bonsembiante F, Canevelli M, Buscarnera S, Cesari M, Banzato T.   +5 more
europepmc   +1 more source