Results 161 to 170 of about 2,220,916 (268)

A Multi-Criteria Decision Framework for Animal Welfare Policy

Policy decisions aimed at improving farm animal welfare involve balancing several competing objectives. Not only do such decisions involve tradeoffs between social, ethical, economic and welfare considerations, animal welfare itself is a multi ...
Hellstrom, J., Bicknell, Kathryn
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

FOSTER: A Comprehensive Pipeline for Transabdominal Fetal Pulse Oximetry Validated in a Large Animal Model of Pregnancy. [PDF]

IEEE Trans Biomed Eng
Kasap B, Saffarpour M, Qian W, Joarder RR, Vali K, Ghiasi S.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Syrian hamster is a valuable animal model for evaluating the transmissibility of emerging influenza viruses. [PDF]

Emerg Microbes Infect
Li J, Wang D, Li B, Ma J, He X, Chen L, Kong H, Deng G, Cui P, Yang H, Meng F, Zeng X, Tian G, Shi J, Chen H.   +14 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Characterization of inflammatory pseudotumors in a large animal model of liver cancer. [PDF]

Animal Model Exp Med
Cressman ENK, Hicks S, Fowlkes NW, Stolley DL, Stenkamp MS.   +4 more
europepmc   +1 more source

Economic Considerations of Animal Welfare Policy

Animal welfare considerations are becoming increasingly important for producers of animal-derived agricultural products. Recent media attention on issues of housing conditions for intensively reared livestock and induced calving in dairy production make ...
Bicknell, Kathryn
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Protection of metabolic-hemodynamic coupling by nimodipine in an animal model of cerebral small vessel disease. [PDF]

J Cereb Blood Flow Metab
Yang Z, Lange F, Xia Y, Tachtsidis I, Smith KJ.   +4 more
europepmc   +1 more source